PXD048058

PXD048058 is an original dataset announced via ProteomeXchange.

Title	SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in hamster model
Description	Seeking a nuanced understanding of host tissue-specific responses and their implications for immunopathogenicity against the SARS-CoV-2 infection was convoluted and not evaluated earlier. We delved into the intricacies of using to understand the complex relationship among acute multi-tissue injury, dysbiosis of the gut microbiota, and the resulting implications for SARS-CoV-2 variant-specific immunopathogenesis in the Golden Syrian hamster (GSH) model. Our investigation revealed increased viremia in diverse tissues of delta-infected GSH compared to the Omicron variant. Multi-omics analyses uncovered distinctive metabolic responses between the delta and omicron variants, with the former demonstrating dysregulation in synaptic transmission proteins associated with neurological disorders. Additionally, delta-infected GSH exhibited an altered fecal microbiota composition, marked by increased inflammatory-associated taxa and reduced commensal bacteria compared to the omicron variant. These findings underscore the SARS-CoV-2-mediated tissue insult, characterized by modified host metabolites, neurological protein dysregulation, and acute gut dysbiosis, highlighting the compromised gut-lung-brain axis during acute infection.
HostingRepository	PRIDE
AnnounceDate	2026-01-05
AnnouncementXML	Submission_2026-01-04_16:28:31.548.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akos Vegvari
SpeciesList	scientific name: Mesocricetus auratus (Golden hamster); NCBI TaxID: NEWT:10036;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-21 15:02:55	ID requested
⏵ 1	2026-01-04 16:28:32	announced

Kaur Sardarni U, Ambikan AT, Acharya A, Johnson SD, Avedissian SN, V, é, gv, á, ri Á, Neogi U, Byrareddy SN, SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in a hamster model. Brain Behav Immun, 123():914-927(2025) [pubmed]

10.1016/j.bbi.2024.10.032;

submitter keyword: omics,SARS-CoV-2, delta, hamster model, omicron, acute COVID-19, PASC, gut-lung-brain axis, tissue-response

Akos Vegvari
contact affiliation	Karolinska Institutet, Stockholm, Sweden
contact email	akos.vegvari@ki.se
lab head
Akos Vegvari
contact affiliation	Karolinska Institutet
contact email	akos.vegvari@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD048058

PRIDE project URI

• PRIDE
  1. PXD048058
     1. Label: PRIDE project
     2. Name: SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in hamster model