PXD048017

PXD048017 is an original dataset announced via ProteomeXchange.

Title	Quantitative Proteomics of Dorsolateral Prefrontal Cortex
Description	Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder with a rising prevalence and genetic and environmental etiologies. Symptoms include deficits in social communication, repetitive patterns of behavior, and cognitive impairment. Neuroanatomic and biochemical investigations involve many brain areas with imbalance between glutamatergic and inhibitory neurotransmitters. We hypothesized that investigation of the synaptic compartment of the dorsolateral prefrontal cortex may provide proteomics signatures that may identify the biological underpinnings of cognitive deficits in childhood ASD. Subcellular fractionation of the synaptoneurosomes from Brodmann area 9 of a well- characterized age- and postmortem-interval-matched samples from children and adults with idiopathic ASD vs. healthy controls, were subjected to HPLC–tandem mass spectrometry and proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:29:04.679.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD048017
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Arthur Eschenlauer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-20 19:27:17	ID requested
⏵ 1	2025-05-06 12:29:05	announced

Fatemi SH, Eschenlauer A, Aman J, Folsom TD, Chekouo T, Quantitative proteomics of dorsolateral prefrontal cortex reveals an early pattern of synaptic dysmaturation in children with idiopathic autism. Cereb Cortex, 34(13):161-171(2024) [pubmed]

10.6019/PXD048017;

10.1093/cercor/bhae044;

submitter keyword: Autism

Brodmann area 9

childhood

proteomics

S.Hossein Fatemi
contact affiliation	Bernstein Professor Emeritus in Adult Psychiatry Department of Psychiatry and Behavioral Sciences University of Minnesota Medical School
contact email	fatem002@umn.edu
lab head
Arthur Eschenlauer
contact affiliation	University of Minnesota, retired
contact email	eschen@alumni.princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD048017

PRIDE project URI

• PRIDE
  1. PXD048017
     1. Label: PRIDE project
     2. Name: Quantitative Proteomics of Dorsolateral Prefrontal Cortex