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PXD048002

PXD048002 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCirculating extracellular vesicles as biomarkers to monitor response to Multiple Sclerosis therapy.
DescriptionIn the last two decades, several disease-modifying treatments (DMTs) have been developed for MS. These therapies are based on the modulation of the immune system and the aim to reduce the disease activity. However, as the natural course of the disease is unpredictable, the benefit of each treatment in each individual patient is still unknown and clinical decisions are very complicated. Some patients initiate treatment but continue with relapses, new lesions in the central nervous system, or show worsening disability. When this occurs, the response of the treatment is considered suboptimal and has to be switched to a more effective treatment, albeit generally with a higher risk of serious adverse effects. Currently, these decisions are made on a case-by-case basis when the lesions in the CNS and the increase in disability have occurred. This is likely due to multiple factors, including the absence of highly predictive, widely used treatment response biomarkers with reasonable sensitivity and specificity that step over the disease heterogeneity and that can be applied in real-life clinical practice. As a result, a high percentage of MS patients do not present adequate control of their disease activity while receiving DMT. In this context, a biomarker that anticipates treatment response or predicts treatment failure would help to make the change before irreversible injury occurs. We aim to analyse whether proteins and miRNAs derived from patients' circulating EVs could provide relevant information about the patient's response to treatment. To build on this, we assessed EV levels, size, microRNA, and protein content from neurons, oligodendrocytes, B and T lymphocytes, pre- and 3 months post-treatment initiation, and correlated with therapeutic response over 12 months in MS patients. Treatment response treatment was evaluated using ‘no evidence of disease activity’ (NEDA5) composite that includes the following clinical parameters: clinical relapses, new lesions on MRI, motor and cognitive disability progression and brain atrophy.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_12:29:04.992.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSusana Bravo
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-12-20 05:53:06ID requested
12025-05-06 12:29:05announced
Publication List
10.3390/ijms251910761;
Torres Iglesias G, L, ó, pez-Molina M, Botella L, Laso-Garc, í, a F, Chamorro B, Fern, á, ndez-Fournier M, Puertas I, Bravo SB, Alonso-L, ó, pez E, D, í, ez-Tejedor E, Guti, é, rrez-Fern, á, ndez M, Otero-Ortega L, Differential Protein Expression in Extracellular Vesicles Defines Treatment Responders and Non-Responders in Multiple Sclerosis. Int J Mol Sci, 25(19):(2024) [pubmed]
Keyword List
submitter keyword: microRNAs, proteomics, treatment response, extracellular vesicles,Biomarkers, multiple sclerosis
Contact List
Susana Bravo
contact affiliationInstituto de Investigaciones Sanitarias de Santiago de Compostela
contact emailSbbravo@gmail.com
lab head
Susana Bravo
contact affiliationFIDIS
contact emailsbbravo@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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