PXD047989

PXD047989 is an original dataset announced via ProteomeXchange.

Title	Project title: Endogenous AIRE-immunoprecipitation from primary human neutrophils
Description	Autoimmune regulator (AIRE) is a transcriptional regulator. We here assess the role for AIRE in primary human neutrophils. We found that the functional role for AIRE in neutrophils is to regulate the extrinsic apoptotic pathway involving the Fas/TNFR death receptors and Cathepsin G and the expression of unique immune mediators.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:24:54.260.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Charlotte Welinder
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-20 03:02:19	ID requested
1	2024-01-25 01:12:38	announced
⏵ 2	2024-10-22 06:24:55	announced	2024-10-22: Updated project metadata.

10.1093/jleuko/qiad152;

K, ä, llberg E, Mehmeti-Ajradini M, Bj, ö, rk Gunnarsdottir F, G, ö, ransson M, Bergenfelz C, Allaoui Fredriksson R, Hagerling C, Johansson ME, Welinder C, Jirstr, ö, m K, Leandersson K, AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation. J Leukoc Biol, 115(4):664-678(2024) [pubmed]

submitter keyword: Neutrophil,AIRE, human

Karin Leandersson
contact affiliation	Karin Leandersson Professor, PhD Cancer Immunology, Department for Translational Medicine, Clinical Research Centre, house 91, floor 11 Jan Waldenströmsg 35, Lund University Skåne University Hospital, Malmö SE-214 28 Malmö, Sweden
contact email	Karin.leandersson@med.lu.se
lab head
Charlotte Welinder
contact affiliation	Dept. of Oncology, Clinical Sciences, Lund University, 221 85 Lund, Sweden
contact email	charlotte.welinder@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD047989

PRIDE project URI

• PRIDE
  1. PXD047989
     1. Label: PRIDE project
     2. Name: Project title: Endogenous AIRE-immunoprecipitation from primary human neutrophils