PXD047958

PXD047958 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated Proteomic Profiling Identifies Amino Acids Selectively Cytotoxic to Pancreatic Cancer Cells
Description	In this study, we carried out a proteomics analysis of cell and extracellular vesicles from nontumor and pancreatic adenocarcinoma (PDAC) tumor cells. We found out that PDAC cells preferentially excrete some proteins with preference for certain amino acids including isoleucine and histidine. Through in vitro and in vivo results, these amino acids demonstrate selective toxicity to PDAC cells and we subsequently identified XRN1 as a potential target of the amino acids.
HostingRepository	PRIDE
AnnounceDate	2024-04-25
AnnouncementXML	Submission_2024-04-25_11:42:04.637.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alfred Akinlalu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-19 10:49:16	ID requested
⏵ 1	2024-04-25 11:42:05	announced

Publication List

10.1016/J.XINN.2024.100626;

10.1016/J.XINN.2024.100626;

Keyword List

submitter keyword: pancreatic adenocarcinoma, proteomics, amino acid treatment, cancer therapy

submitter keyword: pancreatic adenocarcinoma, proteomics, amino acid treatment, cancer therapy

Contact List

Dali Sun
contact affiliation	University of Denver
contact email	dali.sun@du.edu
lab head
Alfred Akinlalu
contact affiliation	University of Denver
contact email	alfred.akinlalu@du.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD047958
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD047958

PRIDE project URI

Repository Record List

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