PXD047899

PXD047899 is an original dataset announced via ProteomeXchange.

Title	BioID-MS of TBX3-proximal proteins in HEK293T cells
Description	Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear b-catenin. Yet, little is known about how b-catenin generates context-specific transcriptional outcomes. Addressing this knowledge gap is pivotal since neoplasia of the colorectal epithelium begins with aberrant Wnt/b-catenin signaling and broadly targeting the Wnt pathway can lead to undesirable consequences. We have previously identified the developmental transcription factor TBX3 as a tissue-specific component of the Wnt/b-catenin nuclear complex during mouse forelimb development. Here, we screen for TBX3-interacting nuclear proteins in HEK293T cells by performing BioID followed by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2025-04-22
AnnouncementXML	Submission_2025-04-22_01:13:17.456.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simon Söderholm
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-18 05:36:18	ID requested
⏵ 1	2025-04-22 01:13:17	announced

Dataset with its publication pending

submitter keyword: TBX3, HEK293T,Wnt, BioID

Claudio Cantù
contact affiliation	Wallenberg Center for Molecular Medicine (WCMM) Department of Biomedical and Clinical Sciences (BKV) Division of Molecular Medicine and Virology (MMV) Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden
contact email	claudio.cantu@liu.se
lab head
Simon Söderholm
contact affiliation	Wallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
contact email	simon.soderholm@liu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD047899

PRIDE project URI

• PRIDE
  1. PXD047899
     1. Label: PRIDE project
     2. Name: BioID-MS of TBX3-proximal proteins in HEK293T cells