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PXD047888

PXD047888 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUSP18-mediated NCOA4 deISGylation and ferroptosis inhibition drives targeted therapy resistance in hepatocellular carcinoma
DescriptionTo elucidate the principal downstream mediator responsible for USP18-mediated Sorafenib resistance in HCC, we conducted cluster analysis on the differential protein expression based on the whole-proteome analysis of HepG2 cells with or without overexpression of USP18 (HepG2-USP18-OE vs. HepG2-Ctrl), we identified 47 commonly downregulated proteins and 31 upregulated proteins .
HostingRepositoryiProX
AnnounceDate2023-12-17
AnnouncementXMLSubmission_2023-12-17_20:26:23.341.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShengtao Ye
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-12-17 20:26:04ID requested
12023-12-17 20:26:23announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: USP18, deISGylation, ferroptosis, targeted therapy resistance, HCC.
Contact List
Hao Zhang
contact affiliationChina Pharmaceutical University
contact emailzhanghao@cpu.edu.cn
lab head
Shengtao Ye
contact affiliationChina Pharmaceutical University
contact emailyst_cpu961223@163.com
dataset submitter
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