PXD047875

PXD047875 is an original dataset announced via ProteomeXchange.

Title	Response of malaria parasites to artemisin compounds and oxidative stress
Description	Artemisin and its derivates are important antimalarials used for treatment of P. falciparum malaria. While the mode of action has been attributed to oxidative stress, methylation and unfolded protein response, the exact mechanism of action of these antimalarials is not known. Here, we used cellular thermal shift assay (CETSA) on live P. falcparum cultures to investigate the MOA of artemesinins using different artemisinin derivates (DHA, ART, AS, ATM and a control drug deoxyART) and different oxidative (di-amide and tert-BOOH) and reducing (DTT,NAC) agents.
HostingRepository	PRIDE
AnnounceDate	2025-05-22
AnnouncementXML	Submission_2025-05-22_04:24:46.800.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Samuel Pazicky
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Plasmodium falciparum (isolate 3D7); NCBI TaxID: 36329;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-17 06:07:30	ID requested
⏵ 1	2025-05-22 04:24:47	announced

10.1016/J.STR.2025.05.008;

submitter keyword: CETSA, malaria, stress, artemisinin, plasmodium

Zbynek Bozdech
contact affiliation	School of Biological Sciences, Nanyang Technological University
contact email	ZBozdech@ntu.edu.sg
lab head
Samuel Pazicky
contact affiliation	School of Biological Sciences, Nanyang Technological University
contact email	samuel.pazicky@ntu.edu.sg
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD047875

PRIDE project URI

• PRIDE
  1. PXD047875
     1. Label: PRIDE project
     2. Name: Response of malaria parasites to artemisin compounds and oxidative stress