PXD047852
PXD047852 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis identifies GSN as non-invasive circulating serum biomarker for predicting early recurrence in hepatocellular carcinoma |
| Description | Hepatocellular carcinoma (HCC) is susceptible to early recurrence and lacks effective predictive markers. Mass Spectrometry (MS)-based proteomics has emerged as a potent tool for identifying cancer biomarker profiles in various bodily fluids. In this study, we established a MS-based biomarker discovery and validation workflow. Firstly, the workflow successfully identified a total of 447 serum proteins in 179 individuals (126 HCC patients and 53 liver cirrhosis (LC)) using the Data Independent Acquisition-MS (DIA-MS) strategy. Then, candidate serum biomarkers were validated in 192 individuals (142 HCC patients and 50 LC patients) using Parallel Reaction Monitoring (PRM) strategy. |
| HostingRepository | iProX |
| AnnounceDate | 2023-12-15 |
| AnnouncementXML | Submission_2024-02-29_18:18:27.740.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaohua Xing |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-12-15 03:36:44 | ID requested | |
| 1 | 2023-12-15 03:37:22 | announced | |
| ⏵ 2 | 2024-02-29 18:18:28 | announced | 2024-03-01: Update information. |
Publication List
| Hu E, Yang T, Cai L, Ouyang J, Wang F, Li Z, Wang Y, Xing X, Liu X, Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma. J Proteome Res, 23(3):1062-1074(2024) [pubmed] |
Keyword List
| submitter keyword: GSN, DIA, serum, PRM |
Contact List
| Xiaolong Liu | |
|---|---|
| contact affiliation | The Liver Center of Fujian Province |
| contact email | xiaoloong.liu@gmail.com |
| lab head | |
| Xiaohua Xing | |
| contact affiliation | The Liver Center of Fujian Province |
| contact email | xingxiaohua2006@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
