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PXD047852

PXD047852 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis identifies GSN as non-invasive circulating serum biomarker for predicting early recurrence in hepatocellular carcinoma
DescriptionHepatocellular carcinoma (HCC) is susceptible to early recurrence and lacks effective predictive markers. Mass Spectrometry (MS)-based proteomics has emerged as a potent tool for identifying cancer biomarker profiles in various bodily fluids. In this study, we established a MS-based biomarker discovery and validation workflow. Firstly, the workflow successfully identified a total of 447 serum proteins in 179 individuals (126 HCC patients and 53 liver cirrhosis (LC)) using the Data Independent Acquisition-MS (DIA-MS) strategy. Then, candidate serum biomarkers were validated in 192 individuals (142 HCC patients and 50 LC patients) using Parallel Reaction Monitoring (PRM) strategy.
HostingRepositoryiProX
AnnounceDate2023-12-15
AnnouncementXMLSubmission_2024-02-29_18:18:27.740.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXiaohua Xing
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-12-15 03:36:44ID requested
12023-12-15 03:37:22announced
22024-02-29 18:18:28announced2024-03-01: Update information.
Publication List
Hu E, Yang T, Cai L, Ouyang J, Wang F, Li Z, Wang Y, Xing X, Liu X, Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma. J Proteome Res, 23(3):1062-1074(2024) [pubmed]
Keyword List
submitter keyword: GSN, DIA, serum, PRM
Contact List
Xiaolong Liu
contact affiliationThe Liver Center of Fujian Province
contact emailxiaoloong.liu@gmail.com
lab head
Xiaohua Xing
contact affiliationThe Liver Center of Fujian Province
contact emailxingxiaohua2006@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI