PXD047838

PXD047838 is an original dataset announced via ProteomeXchange.

Title	Skeletal Muscle Proteome of Cachectic Pancreatic Cancer Patients
Description	Cancer cachexia is a multifactorial condition characterized by skeletal muscle loss that impairs longevity and quality of life of the vast majority of cancer patients. However, the ability to develop therapeutic strategies to counter cachexia is impeded by the limited understanding of the underlying mechanisms of cachexia in human cancer patients. The purpose of this study was therefore to characterize the proteomic signature of skeletal muscle obtained from cachectic pancreatic ductal adenocarcinoma (PDAC) patients, who exhibit one of the highest rates of cachexia. Muscle biopsies (rectus abdominis) were obtained from PDAC patients (n=8; 70±10yr; BMI: 26.8±5.9kg･m-2) undergoing tumor resection surgery as well as age and sex-matched non-cancer controls (n=6; 66±9yr; BMI: 30.8±5.2kg･m-2). PDAC patients were cachectic (6 month body weight loss > 5%; mean: 15.7±7.9%) and did not undergo neoadjuvant therapy.
HostingRepository	PRIDE
AnnounceDate	2025-06-23
AnnouncementXML	Submission_2025-06-22_16:05:37.655.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andrew D'Lugos
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-14 13:43:55	ID requested
⏵ 1	2025-06-22 16:05:38	announced

10.1172/jci178806;

D'Lugos AC, Ducharme JB, Callaway CS, Trevino JG, Atkinson C, Judge SM, Judge AR, Complement pathway activation mediates pancreatic cancer-induced muscle wasting and pathological remodeling. J Clin Invest, 135(12):(2025) [pubmed]

submitter keyword: cachexia, Orbitrap Fusion Lumos,Skeletal muscle, rectus abdominis, pancreatic cancer, PDAC

Andrew R. Judge
contact affiliation	Professor Department of Physical Therapy University of Florida Gainesville, FL U.S.A.
contact email	arjudge@phhp.ufl.edu
lab head
Andrew D'Lugos
contact affiliation	California State University, Chico
contact email	acdlugos@csuchico.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD047838

PRIDE project URI

• PRIDE
  1. PXD047838
     1. Label: PRIDE project
     2. Name: Skeletal Muscle Proteome of Cachectic Pancreatic Cancer Patients