PXD047823

PXD047823 is an original dataset announced via ProteomeXchange.

Title	Discrimination of etiologically different cholestasis by modeling proteomics datasets
Description	Cholestasis is characterized by disrupted bile flow from the liver to the small intestine. Although etiologically different cholestasis display similar symptoms, diverse factors can contribute to the progression of the disease and determines the appropriate therapeutic option. Therefore, stratifying cholestatic patients is essential for the development of tailor-made treatment strategies. Here, we have analyzed the liver proteome from cholestatic patients of different etiology. 7,161 proteins were identified and quantified, of which 263 were differentially expressed between control and cholestasis groups. These differential proteins point to deregulated cellular processes that explain part of the molecular framework of cholestasis progression. However, the clustering of different cholestasis types was limited. Therefore, a machine learning pipeline was designed to identify a panel of 20 differential proteins that segregate different cholestasis groups with high accuracy and sensitivity. In summary, proteomics combined with machine learning algorithms provides valuable insights into the molecular mechanisms of cholestasis progression and a panel of proteins to discriminate across different types of cholestasis. This strategy may prove useful to develop precision medicine approaches for patient care.
HostingRepository	PRIDE
AnnounceDate	2024-05-22
AnnouncementXML	Submission_2024-05-22_02:38:58.531.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD047823
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Laura Guerrero
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-14 04:00:31	ID requested
⏵ 1	2024-05-22 02:38:59	announced

10.6019/PXD047823;

10.3390/ijms25073684;

Guerrero L, Vindel-Alfageme J, Hierro L, Stark L, Vicent D, Sorzano C Ó S, Corrales FJ, Discrimination of Etiologically Different Cholestasis by Modeling Proteomics Datasets. Int J Mol Sci, 25(7):(2024) [pubmed]

submitter keyword: Human, liver, cholestasis

Fernando Corrales
contact affiliation	CNB-CSIC
contact email	fcorrales@cnb.csic.es
lab head
Laura Guerrero
contact affiliation	CNB-CSIC
contact email	lguerrero@cnb.csic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD047823

PRIDE project URI

• PRIDE
  1. PXD047823
     1. Label: PRIDE project
     2. Name: Discrimination of etiologically different cholestasis by modeling proteomics datasets