PXD047794

PXD047794 is an original dataset announced via ProteomeXchange.

Title	African swine fever virus proteins MGF360-21R and A151R interact with barrier-to-autointegration factor 1 (BANF1)
Description	African swine fever virus (ASFV) is a large DNA virus causing a highly contagious disease in domestic and wild boar, for which no treatment is available. ASFV vaccine development is hindered by large gaps in knowledge considering virus protein function and virus-host interaction. This study identifies the interaction between two ASFV proteins, MGF360-21R and A151R, and a host barrier-to-autointegration factor 1 (BANF1). We showed that proteins MGF360-21R and A151R can inhibit the induction of the IFN response. Additionally, BANF1 was determined as an important factor in ASFV infection, as the downregulation of BANF1 reduces virus replication. These results uncover a novel function of viral proteins MGF360-21R and A151R and extend our understanding of complex interaction between virus and host, providing insights for developing a vaccine to prevent and control ASFV.
HostingRepository	PRIDE
AnnounceDate	2025-07-23
AnnouncementXML	Submission_2025-07-23_04:04:11.099.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Katarzyna Dolata
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-13 08:40:38	ID requested
⏵ 1	2025-07-23 04:04:11	announced

10.1016/J.MCPRO.2025.101038;

submitter keyword: MGF360-21R, A151R, ASFV,BANF1, virus-host PPI

Katarzyna Dolata
contact affiliation	Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
contact email	katarzyna.dolata@fli.de
lab head
Katarzyna Dolata
contact affiliation	Friedrich-Loeffler Institut
contact email	katarzyna.dolata@fli.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD047794
     1. Label: PRIDE project
     2. Name: African swine fever virus proteins MGF360-21R and A151R interact with barrier-to-autointegration factor 1 (BANF1)