PXD047778

PXD047778 is an original dataset announced via ProteomeXchange.

Title	Deep Proteomic Analysis for Non-Invasive Left Atrial Appendage Thrombus Prediction in Patients with Non-Valvular Atrial Fibrillation
Description	Methods: Deep proteomic analysis on plasma from 8 non-valvular AF patients categorized into thrombus and control groups based on LAAT presence was conducted. Identified biomarkers were validated using enzyme-linked immunosorbent assay in a cohort of 179 patients, with clinical, transthoracic echocardiography, and transesophageal echocardiography data collected. A Lasso regression-based predictive model was constructed. Results: The Thrombus group had higher CHA2DS2-VASc scores, larger left atrial appendage thrombus (LAA) diameter, and lower LAA flow velocity. Deep proteomic analysis identified 30 differentially expressed proteins, with MYL4, PCYOX1, and DCN selected as diagnostic biomarkers (P<0.0001). The model included MYL4, PCYOX1, DCN, LAA cauliflower morphology, and CHA2DS2-VASc score. The model's area under the curve is 0.983. Additionally, net reclassification improvement and integrated discrimination improvement indices were also calculated, yielding values of 1.797 and 0.740, respectively, indicating a substantial improvement in risk prediction and classification over the conventional CHA2DS2-VASc model alone. Conclusions: Elevated MYL4, decreased PCYOX1 and DCN levels, and cauliflower LAA morphology are independent risk factors. Incorporating these variables into the prediction model improves the diagnostic performance of the LAAT prediction model, potentially offering a non-invasive and clinically valuable approach to stroke prevention. Keywords: Atrial Fibrillation; Thrombosis; Proteomics
HostingRepository	iProX
AnnounceDate	2023-12-12
AnnouncementXML	Submission_2024-06-30_20:56:30.108.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhonghui Xie
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-12 21:59:32	ID requested
⏵ 1	2024-06-30 20:56:30	announced

Dataset with its publication pending

submitter keyword: Atrial Fibrillation, Thrombosis, Proteomics

Yang Li
contact affiliation	Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Fucheng Road, Haidian District, Beijing 100048, China
contact email	liyangbss@163.com
lab head
Zhonghui Xie
contact affiliation	Department of Cardiology, Tianjin Medical University General Hospital, Tianjin 300052, China
contact email	xiezhonghui92@163.com
dataset submitter

iProX dataset URI