PXD047740

PXD047740 is an original dataset announced via ProteomeXchange.

Title	AKAP1/PKA-mediated GRP75 phosphorylation at MAMs sequesters GRP75 outside the mitochondria to protect cancer cells against ferroptosis
Description	In this study, we found that GRP75 is redistributed outside of mitochondria as a result of its increased phosphorylation and protects cancer cells from ferroptosis by directly binding with Kelch-like ECH-associated protein 1 (Keap1), at MAMs and in the cytosol, leading to reduced Keap1-mediated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2).
HostingRepository	iProX
AnnounceDate	2023-12-12
AnnouncementXML	Submission_2024-01-30_18:34:04.011.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hao Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-11 23:54:01	ID requested
⏵ 1	2024-01-30 18:34:04	announced

Dataset with its publication pending

submitter keyword: Glucose response protein 75 (GRP75), A-kinase anchor protein 1(AKAP1), Protein Kinase A (PKA), Phosphorylation, Mitochondria-associated endoplasmic reticulum membranes (MAMs), Ferroptosis

Ying Hu
contact affiliation	Harbin Institute of Technology
contact email	huying@hit.edu.cn
lab head
Hao Liu
contact affiliation	Harbin Institute of Technology
contact email	2315487514@qq.com
dataset submitter

iProX dataset URI