PXD047649

PXD047649 is an original dataset announced via ProteomeXchange.

Title	A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis
Description	Hydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of oxygen has resulted in the loss of the membrane- associated respiratory chain, and consequently in the generation of minimal inner membrane potential (), and inefficient ATP synthesis via substrate-level phosphorylation. The changes in energy metabolism are directly linked with the organelle biogenesis. In mitochondria, proteins are imported across the outer membrane via the Translocase of the Outer Membrane (TOM complex), while two Translocases of the Inner Membrane, TIM22, and TIM23, facilitate import to the inner membrane and matrix. TIM23-mediated steps are entirely dependent on  and ATP hydrolysis, while TIM22 requires only . The character of the hydrogenosomal inner membrane translocase and the mechanism of translocation is currently unknown.
HostingRepository	PRIDE
AnnounceDate	2024-06-16
AnnouncementXML	Submission_2024-06-15_23:11:33.797.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Karel Harant
SpeciesList	scientific name: Trichomonas vaginalis; NCBI TaxID: 5722;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-08 06:24:21	ID requested
⏵ 1	2024-06-15 23:11:34	announced

10.1186/s12915-024-01928-8;

Makki A, Kere, ï, che S, Le T, Ku, č, erov, á J, Rada P, Ž, á, rsk, ý V, Hrd, ý I, Tachezy J, A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis. BMC Biol, 22(1):130(2024) [pubmed]

submitter keyword: presequence translocase-associated motor, parasite, protein import machinery, TIM22 complex, mitochondria, TIM23 complex, Trichomonas vaginalis,hydrogenosomes

Jan Tachezy
contact affiliation	1Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Průmyslová 595, 25250 Vestec, Czech Republic
contact email	tachezy@natur.cuni.cz
lab head
Karel Harant
contact affiliation	Charles University
contact email	harant@natur.cuni.cz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD047649

PRIDE project URI

• PRIDE
  1. PXD047649
     1. Label: PRIDE project
     2. Name: A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis