PXD047623

PXD047623 is an original dataset announced via ProteomeXchange.

Title	Impact of a tailored exercise regimen on physical capacity, systemic oxidative stress and plasma proteomic profile in PCC patients
Description	Individuals affected by post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicate the contrary. The goal of this study is to determine the impact of a closely monitored 8-week mixed exercise program on physical capacity, symptoms, fatigue, systemic oxidative stress and plasma proteomic profiles of PCC cases. Methods: Twenty-five women and men with PCC assigned sequentially to exercise (n = 15) and non-exercise (n = 10) groups. Individuals with no PCC served as a control group. The exercise program included cardiovascular and resistance exercises. Physical capacity, physical activity level and the presence of common PCC symptoms were measured before and after the intervention. Fatigue was measured the day following each exercise session. Plasma and PBMC samples were collected at the beginning and end of the training program. Glutathione and deoxyguanosine levels in PBMC and plasma proteomic profiles were evaluated. Results: Bicep Curl (p=0.040) and STS-30 (p=0.043) improved to a greater extent in the exercise group than in the non-exercise group. An interaction effect was also observed for the level of physical activity (p=0.007) with a positive effect of the program on their daily functioning and without any adverse effects on general or post-effort fatigue. Glutathione levels showed marked improvement after exercise. Discernable changes were observed in the plasma proteomics profile with certain proteins involved in inflammatory response (SA100A8) decreasing in the exercise group. Conclusion: Supervised exercise adapted to the level of fatigue and ability is safe and effective in PCC patients in improving their general physical capacity and wellbeing. Systemic molecular markers that accompany physical improvement can be monitored by analyzing plasma proteomics and markers of oxidative stress. Large-scale studies will help identify promising molecular markers to objectively monitor patient improvement.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_05:54:18.629.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jean-Francois Lucier
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue
Instrument	Bruker Daltonics instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-07 11:00:06	ID requested
⏵ 1	2024-10-17 05:54:19	announced

Chowdhury MMH, Fontaine MN, Lord SE, Quenum AJI, Limoges MA, Rioux-Perreault C, Lucier JF, Cliche DO, Levesque D, Boisvert FM, Cantin AM, Allard-Chamard H, Menendez A, Ilangumaran S, Pich, é A, Dionne IJ, Ramanathan S, Impact of a tailored exercise regimen on physical capacity and plasma proteome profile in post-COVID-19 condition. Front Physiol, 15():1416639(2024) [pubmed]

10.3389/fphys.2024.1416639;

submitter keyword: Physical activity, Exercise, Physical capacity, Plasma proteomics, Fatigue, Symptoms,Long COVID, Post COVID-19 condition, Oxidative stress

Sheela Ramanathan
contact affiliation	Departments of Immunology and Cell Biology Faculty of Medicine and Health Sciences Université de Sherbrooke Sherbrooke, QC J1H 5N4 Canada
contact email	sheela.ramanathan@usherbrooke.ca
lab head
Jean-Francois Lucier
contact affiliation	Universite de Sherbrooke
contact email	jean-francois.lucier@usherbrooke.ca
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD047623
     1. Label: PRIDE project
     2. Name: Impact of a tailored exercise regimen on physical capacity, systemic oxidative stress and plasma proteomic profile in PCC patients