PXD047547

PXD047547 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond: LC-MS/MS Dataset
Description	LC-MS/MS analysis of a gel slice containing a disulfide-cross-linked peptide chains between thioredoxin-1 and the NACHT-LRR domains of NLRP1
HostingRepository	PRIDE
AnnounceDate	2025-05-26
AnnouncementXML	Submission_2025-05-25_16:06:20.509.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Geeson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	hydrolyzed N-methylmaleimide cysteine adduct; N-methylmaleimide modified L-cysteine; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-05 14:05:35	ID requested
⏵ 1	2025-05-25 16:06:21	announced

Publication List

Geeson MB, Hsiao JC, Tsamouri LP, Ball DP, Bachovchin DA, The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond. Cell Chem Biol, 31(5):955-961.e4(2024) [pubmed]
10.1016/j.chembiol.2023.12.012;

Geeson MB, Hsiao JC, Tsamouri LP, Ball DP, Bachovchin DA, The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond. Cell Chem Biol, 31(5):955-961.e4(2024) [pubmed]

10.1016/j.chembiol.2023.12.012;

Keyword List

submitter keyword: disulfide, LC-MS,NLRP1, TRX1

submitter keyword: disulfide, LC-MS,NLRP1, TRX1

Contact List

Daniel A. Bachovchin
contact affiliation	1) Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, USA. 2) Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. 3) Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
contact email	bachovcd@mskcc.org
lab head
Michael Geeson
contact affiliation	Sloan Kettering Institute
contact email	mike.geeson@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD047547
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD047547

PRIDE project URI

Repository Record List

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