PXD047470

PXD047470 is an original dataset announced via ProteomeXchange.

Title	Proteomics profiling of tumor-derived extracellular vesicles for triple-negative breast cancer
Description	Tumor-derived extracellular vesicles (tdEVs) have been emerging as potential biomarkers for cancer diagnosis because the tdEVs precisely reflect tumor cell alterations with significantly increased production. The proteomic profiling study of tdEVs represents a promising approach in a non-invasive manner to novel biomarker discovery for early detection and targeted therapy of cancer. Previously, we have developed a novel microfluidic chip for rapid and selective isolation of tdEVs. This microfluidic chip enables the selection of two types of EVs by using breast tumor-derived proteins (EpiCAM & CD49f) within two minutes. Using a microfluidic chip capable of selectively isolating tdEVs, the study compared the proteomes of EVs isolated from the serum of 100 breast cancer patients with different subtypes and 30 healthy individuals.
HostingRepository	PRIDE
AnnounceDate	2025-06-23
AnnouncementXML	Submission_2025-06-23_02:02:50.412.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juyong Hyon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-03 06:48:57	ID requested
⏵ 1	2025-06-23 02:02:50	announced

10.1002/JEV2.70089;

submitter keyword: Human, LC-MSMS, TNBC, Serum, Microfludics, Exosome

Young-Ho Chung
contact affiliation	Research Center for Bioconvergence Analysis, Korea Basic Science Institute (KBSI, Republic of Korea )
contact email	chungyh@kbsi.re.kr
lab head
Juyong Hyon
contact affiliation	Korea Basic Science Institute
contact email	hjy1234@kbsi.re.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD047470

PRIDE project URI

• PRIDE
  1. PXD047470
     1. Label: PRIDE project
     2. Name: Proteomics profiling of tumor-derived extracellular vesicles for triple-negative breast cancer