Update information. The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease’s extensive and sustained symptoms are now becoming a nonnegligible medical challenge. In this respect, data show that heart failure is one of the most common readmission diagnoses among COVID-19 patients. In this study, we used human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes to develop an in vitro severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection model and studied the dynamic changes occurring in cardiomyocytes after SARS-CoV-2 infection. Our findings highlight the importance of early detection and personalized treatment based on the disease stage. Finally, when our proteomics findings were combined with those of a virus-host interaction network analysis, we were able to identify several potential drug targets for the disease.