PXD047411 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Kinome profiling of skeletal muscle from a mouse model of pancreatic cancer-induced cachexia |
Description | More than 85% of patients with pancreatic ductal adenocarcinoma (PDAC) suffer from cachexia, a debilitating syndrome characterized by loss of muscle and fat. To model PDAC cachexia in mice, 12-week-old C57BL/6J male mice were implanted with the cachexia inducing pancreatic cell line, KPC32908, into the pancreas. Controls underwent a sham surgery. Mice were euthanized under isoflurane anesthesia when the tumor-bearing mice exhibited cachexia, including ~18% loss of quadriceps mass versus sham controls. Quadriceps muscle was flash frozen at euthanasia. 1mg quadriceps protein lysate per sample was used for kinome profiling. |
HostingRepository | PRIDE |
AnnounceDate | 2025-04-21 |
AnnouncementXML | Submission_2025-04-21_09:48:46.564.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Steven Angus |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-30 09:50:38 | ID requested | |
⏵ 1 | 2025-04-21 09:48:46 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: PDAC, muscle atrophy, kinase inhibitor beads, muscle wasting |
Contact List
Teresa Zimmers |
contact affiliation | Indiana University School of Medicine |
contact email | zimmerst@iu.edu |
lab head | |
Steven Angus |
contact affiliation | Indiana University School of Medicine |
contact email | sangus@iu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD047411 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047411
- Label: PRIDE project
- Name: Kinome profiling of skeletal muscle from a mouse model of pancreatic cancer-induced cachexia