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PXD047411

PXD047411 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleKinome profiling of skeletal muscle from a mouse model of pancreatic cancer-induced cachexia
DescriptionMore than 85% of patients with pancreatic ductal adenocarcinoma (PDAC) suffer from cachexia, a debilitating syndrome characterized by loss of muscle and fat. To model PDAC cachexia in mice, 12-week-old C57BL/6J male mice were implanted with the cachexia inducing pancreatic cell line, KPC32908, into the pancreas. Controls underwent a sham surgery. Mice were euthanized under isoflurane anesthesia when the tumor-bearing mice exhibited cachexia, including ~18% loss of quadriceps mass versus sham controls. Quadriceps muscle was flash frozen at euthanasia. 1mg quadriceps protein lysate per sample was used for kinome profiling.
HostingRepositoryPRIDE
AnnounceDate2025-04-21
AnnouncementXMLSubmission_2025-04-21_09:48:46.564.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSteven Angus
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-30 09:50:38ID requested
12025-04-21 09:48:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: PDAC, muscle atrophy, kinase inhibitor beads, muscle wasting
Contact List
Teresa Zimmers
contact affiliationIndiana University School of Medicine
contact emailzimmerst@iu.edu
lab head
Steven Angus
contact affiliationIndiana University School of Medicine
contact emailsangus@iu.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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