PXD047411

PXD047411 is an original dataset announced via ProteomeXchange.

Title	Kinome profiling of skeletal muscle from a mouse model of pancreatic cancer-induced cachexia
Description	More than 85% of patients with pancreatic ductal adenocarcinoma (PDAC) suffer from cachexia, a debilitating syndrome characterized by loss of muscle and fat. To model PDAC cachexia in mice, 12-week-old C57BL/6J male mice were implanted with the cachexia inducing pancreatic cell line, KPC32908, into the pancreas. Controls underwent a sham surgery. Mice were euthanized under isoflurane anesthesia when the tumor-bearing mice exhibited cachexia, including ~18% loss of quadriceps mass versus sham controls. Quadriceps muscle was flash frozen at euthanasia. 1mg quadriceps protein lysate per sample was used for kinome profiling.
HostingRepository	PRIDE
AnnounceDate	2025-04-21
AnnouncementXML	Submission_2025-04-21_09:48:46.564.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Steven Angus
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-30 09:50:38	ID requested
⏵ 1	2025-04-21 09:48:46	announced

Dataset with its publication pending

submitter keyword: PDAC, muscle atrophy, kinase inhibitor beads, muscle wasting

Teresa Zimmers
contact affiliation	Indiana University School of Medicine
contact email	zimmerst@iu.edu
lab head
Steven Angus
contact affiliation	Indiana University School of Medicine
contact email	sangus@iu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD047411

PRIDE project URI

• PRIDE
  1. PXD047411
     1. Label: PRIDE project
     2. Name: Kinome profiling of skeletal muscle from a mouse model of pancreatic cancer-induced cachexia