PXD047391

PXD047391 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Impact of Cerium Oxide Nanoparticles on Rat Myoblast Proteome
Description	Oxidative stress is a widespread causative agent of disease. Together with its general relevance for biomedicine, such dynamic is recognizably detrimental to space exploration. Among other solutions, cerium oxide nanoparticles (or nanoceria, NC) display a long-lasting, self-renewable antioxidant activity. In a previous experiment, we evaluated oxidative imbalance in rat myoblasts in space – aboard the International Space Station –, and unveiled possible protective effects from NC through RNA sequencing. Here we focus on myoblast response to NC on land by means of proteomics, defining a list of proteins that putatively react to NC and confirming nucleosomes/histones as likely mediators of its molecular action.
HostingRepository	PRIDE
AnnounceDate	2025-06-09
AnnouncementXML	Submission_2025-06-08_16:10:16.648.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andrea Armirotti
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-29 23:08:53	ID requested
⏵ 1	2025-06-08 16:10:17	announced

Publication List

10.1021/acsomega.3c09715;
Degl'Innocenti A, Braccia C, Genchi GG, di Leo N, Leoncino L, Catalano F, Armirotti A, Ciofani G, Proteome Alterations and Nucleosome Activation in Rat Myoblasts Treated with Cerium Oxide Nanoparticles. ACS Omega, 9(27):29226-29233(2024) [pubmed]

10.1021/acsomega.3c09715;

Degl'Innocenti A, Braccia C, Genchi GG, di Leo N, Leoncino L, Catalano F, Armirotti A, Ciofani G, Proteome Alterations and Nucleosome Activation in Rat Myoblasts Treated with Cerium Oxide Nanoparticles. ACS Omega, 9(27):29226-29233(2024) [pubmed]

Keyword List

submitter keyword: proteomics,nanoceria, nanoparticles

submitter keyword: proteomics,nanoceria, nanoparticles

Contact List

Andrea Armirotti
contact affiliation	Analytical Chemistry Facility, Istituto Italiano di Tecnologia
contact email	andrea.armirotti@iit.it
lab head
Andrea Armirotti
contact affiliation	Analytical Chemistry Lab, Fondazione Istituto Italiano di Tecnologia
contact email	andrea.armirotti@iit.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD047391
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD047391

PRIDE project URI

Repository Record List

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