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PXD047381

PXD047381 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe synaptic proteome and phosphoproteome is uniquely vulnerable to sleep loss during brain development while maturation confers resilience
DescriptionSleep supports lifelong brain health and cognition. Sleep loss in early life can drive lasting changes in adult behavior, indicating sleep plays a distinct but poorly understood role supporting brain development. We systematically examined the molecular and behavioral adaptations and synaptic consequences of acute sleep deprivation (SD) in developing and adult mice. Developing mice lack robust adaptations to SD, exacerbating cognitive deficits. Synapse proteome and phosphoproteome analysis revealed profound vulnerability to SD in developing mice, including immediate impacts on synaptogenesis and key aspects of brain development. With maturation, a unified biochemical effect of sleep on synapses emerges, together with robust adaptations and resilience to SD. Our findings show sleep plays a distinct role in early life supporting synapse development, transitioning to homeostatic functions with maturation.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_07:00:55.663.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChristine Mills
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-29 08:19:11ID requested
12024-10-08 14:37:38announced
22024-10-22 07:00:56announced2024-10-22: Updated project metadata.
Publication List
Gay SM, Chartampila E, Lord JS, Grizzard S, Maisashvili T, Ye M, Barker NK, Mordant AL, Mills CA, Herring LE, Diering GH, Developing forebrain synapses are uniquely vulnerable to sleep loss. bioRxiv, ():(2024) [pubmed]
10.1101/2023.11.06.565853;
Keyword List
submitter keyword: Synapses
Brain development
Sleep
Sleep deprivation
Contact List
Graham Diering
contact affiliationUniversity of North Carolina at Chapel Hill; Cell Biology Department
contact emailgraham_diering@med.unc.edu
lab head
Christine Mills
contact affiliationUniversity of North Carolina - Chapel Hill
contact emailallie.mills@unc.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
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