PXD047362 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Total proteome of SK-N-BE2 cells expressing individual VZV ORF |
Description | The alpha-herpesvirus Varicella-Zoster Virus (VZV), the causative agent of chicken pox, infects most humans worldwide and remains latent in peripheral neuronal cells for life. Its reactivation triggers herpes zoster and sporadic disseminated infection, in particular in the central nervous system (CNS) where it is associated with severe pathologies. VZV replication is efficiently controlled with antivirals, however the emergence of treatment-resistant VZV variants constitutes an increasing healthcare issue, calling for in-depth analysis of molecular VZV-host interactions to foster general knowledge and promote identification of novel therapeutic targets. Here we conducted a mass spectrometry-based survey in neuronal SK-N-BE2 cells, combining proteome analysis of VZV-infected cells with systematic characterization of VZV proteins’ functions through identifying their individual host partners and effects on the host proteome. In this dataset, we systematically assessed proteome changes elicited by the expression of individual viral proteins – the so called “effectome”, which allowed us to gain unprecedented insights in the activity of individual VZV ORFs. |
HostingRepository | PRIDE |
AnnounceDate | 2025-07-15 |
AnnouncementXML | Submission_2025-07-15_08:37:48.807.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Virginie Girault |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Human alphaherpesvirus 3; NCBI TaxID: 10335; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-28 23:00:46 | ID requested | |
⏵ 1 | 2025-07-15 08:37:49 | announced | |
Publication List
Keyword List
submitter keyword: effectome,VZV, Human, SK-N-BE2, VZV ORF |
Contact List
Andreas Pichlmair |
contact affiliation | Institute of Virology, Technical University of Munich, Munich, Germany. |
contact email | andreas.pichlmair@tum.de |
lab head | |
Virginie Girault |
contact affiliation | Institute of Virology - Technical University Munich |
contact email | v.girault@tum.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD047362 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047362
- Label: PRIDE project
- Name: Total proteome of SK-N-BE2 cells expressing individual VZV ORF