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PXD047362

PXD047362 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTotal proteome of SK-N-BE2 cells expressing individual VZV ORF
DescriptionThe alpha-herpesvirus Varicella-Zoster Virus (VZV), the causative agent of chicken pox, infects most humans worldwide and remains latent in peripheral neuronal cells for life. Its reactivation triggers herpes zoster and sporadic disseminated infection, in particular in the central nervous system (CNS) where it is associated with severe pathologies. VZV replication is efficiently controlled with antivirals, however the emergence of treatment-resistant VZV variants constitutes an increasing healthcare issue, calling for in-depth analysis of molecular VZV-host interactions to foster general knowledge and promote identification of novel therapeutic targets. Here we conducted a mass spectrometry-based survey in neuronal SK-N-BE2 cells, combining proteome analysis of VZV-infected cells with systematic characterization of VZV proteins’ functions through identifying their individual host partners and effects on the host proteome. In this dataset, we systematically assessed proteome changes elicited by the expression of individual viral proteins – the so called “effectome”, which allowed us to gain unprecedented insights in the activity of individual VZV ORFs.
HostingRepositoryPRIDE
AnnounceDate2025-07-15
AnnouncementXMLSubmission_2025-07-15_08:37:48.807.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVirginie Girault
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Human alphaherpesvirus 3; NCBI TaxID: 10335;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-28 23:00:46ID requested
12025-07-15 08:37:49announced
Publication List
10.1038/S41564-025-02068-7;
Keyword List
submitter keyword: effectome,VZV, Human, SK-N-BE2, VZV ORF
Contact List
Andreas Pichlmair
contact affiliationInstitute of Virology, Technical University of Munich, Munich, Germany.
contact emailandreas.pichlmair@tum.de
lab head
Virginie Girault
contact affiliationInstitute of Virology - Technical University Munich
contact emailv.girault@tum.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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