PXD047357

PXD047357 is an original dataset announced via ProteomeXchange.

Title	IRAP regulates platelet reactivity and granule secretion in sepsis
Description	We focused on a recycling endosome marker protein, insulin-responsive aminopeptidase (IRAP), which has not been reported in platelets. IRAP (Lnpep) gene variants have been reported to be associated with ischemic stroke and septic shock. The regulatory transport of IRAP depends on the cytosolic domain of the enzyme, which has been shown to interact with several proteins involved in vesicle formation or cytoskeleton remodeling; For example, Golgin p115, Vimentin and FHOD1(Formin homologous domain containing protein 1). IRAP has been reported to be involved in mast cell degranulation, dendritic cell phagosomal maturation and TLR9 signaling, and CD3 signaling in T cells.6–9 IRAP enzyme activity is also involved in antigen processing during major histocompatibility complex class I (MHC-I) cross presentation, and its marker endosomes can be degraded by autophagy.
HostingRepository	iProX
AnnounceDate	2023-11-29
AnnouncementXML	Submission_2023-11-28_19:43:06.300.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Baichuan Xu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-28 19:39:19	ID requested
⏵ 1	2023-11-28 19:43:06	announced

Dataset with its publication pending

submitter keyword: IRAP/LNPEP, Ribosome, Megakaryocyte/platelet, Sepsis, Thrombosis

Junping Wang
contact affiliation	Army Medical University
contact email	wangjunping@tmmu.edu.cn
lab head
Baichuan Xu
contact affiliation	Army Medical University
contact email	xubaichuan1998@foxmail.com
dataset submitter

iProX dataset URI