PXD047302
PXD047302 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Serum proteomic biomarker investigation of vascular depression using data-independent acquisition (DIA): a pilot study |
| Description | Vascular depression (VaD) is considered a depressive syndrome occurring associated with cerebrovascular disease and vascular risk factors. The study aims to analyze the proteomic signature and identify promising biomarkers with diagnostic significance for vascular depression (VaD). Deep profiling of serum proteome in vascular depression (VaD) patients(n=35) and age/sex matched controls(n=36) were analyzed by bioinformatics and machine learning, our results uncovered several potential biomolecular markers (eg, FTO) and biological pathways (eg, synaptic vesicle cycle) related to VaD. Monitoring protease expression differences can help in the diagnosis and prognosis of VaD. We believe this manuscript will provide new issues for readers working on the field of depression among the elderly. |
| HostingRepository | iProX |
| AnnounceDate | 2023-11-28 |
| AnnouncementXML | Submission_2024-03-06_00:12:51.814.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Junjian Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-11-27 20:12:57 | ID requested | |
| 1 | 2023-11-27 21:21:56 | announced | |
| ⏵ 2 | 2024-03-06 00:12:53 | announced | 2024-03-06: Update information. |
Publication List
| Lan L, Peng S, Zhang R, He H, Yang Y, Xi B, Zhang J, Serum proteomic biomarker investigation of vascular depression using data-independent acquisition: a pilot study. Front Aging Neurosci, 16():1341374(2024) [pubmed] |
Keyword List
| submitter keyword: vascular depression, proteome, machine learning, biomarker |
Contact List
| Junjian Zhang | |
|---|---|
| contact affiliation | Department of Neurology, Zhongnan Hospital, Wuhan University |
| contact email | zhangjj@whu.edu.cn |
| lab head | |
| Junjian Zhang | |
| contact affiliation | Department of Neurology, Zhongnan Hospital, Wuhan University |
| contact email | zhangjj@whu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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