PXD047284

PXD047284 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of cancer-related alterations in the human unfoldome
Description	In this study, we explore the role of intrinsically disordered proteins (IDPs) in human breast cancer within the context of the "unfoldome." Using advanced proteomic techniques, we identified 2,271 protein groups in both normal and cancerous cell proteomes. Notably, 148 IDPs displayed significant differential expression in cancer cells, with a particular focus on cancer-related proteins. In our functional annotation, we found that 65% of these IDPs were linked to various diseases, with 20% specifically associated with cancer. Moreover, a substantial portion of the differentially expressed IDPs contained disordered regions, as verified through in silico characterization. By classifying IDPs into major Gene Ontology categories and conducting pathway analysis, our results highlight a high degree of interactivity within the altered portion of the human unfoldome in cancer, emphasizing the prevalence of moderately and highly disordered proteins in these networks. This study further elucidates the pivotal role of IDPs in the molecular mechanisms of breast cancer.
HostingRepository	PRIDE
AnnounceDate	2024-05-21
AnnouncementXML	Submission_2024-05-21_11:18:57.420.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD047284
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lincoln Liburd
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-27 09:35:02	ID requested
⏵ 1	2024-05-21 11:18:58	announced

Publication List

Paromov V, Uversky VN, Cooley A, Liburd LE, Mukherjee S, Na I, Dayhoff GW, Pratap S, The Proteomic Analysis of Cancer-Related Alterations in the Human Unfoldome. Int J Mol Sci, 25(3):(2024) [pubmed]
10.6019/PXD047284;
10.3390/ijms25031552;

Paromov V, Uversky VN, Cooley A, Liburd LE, Mukherjee S, Na I, Dayhoff GW, Pratap S, The Proteomic Analysis of Cancer-Related Alterations in the Human Unfoldome. Int J Mol Sci, 25(3):(2024) [pubmed]

10.6019/PXD047284;

10.3390/ijms25031552;

Keyword List

submitter keyword: Unfoldome, IDPs,Cancer

submitter keyword: Unfoldome, IDPs,Cancer

Contact List

Dr. Siddharth Pratap
contact affiliation	Director of Bioinformatics and Proteomics, Meharry Medical College; Adjunct Associate Professor, Department of Biomedical Informatics, Vanderbilt University Medical Center
contact email	spratap@mmc.edu
lab head
Lincoln Liburd
contact affiliation	Meharry Medical College
contact email	lliburd23@email.mmc.edu
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD047284

PRIDE project URI

Repository Record List

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