PXD047281

PXD047281 is an original dataset announced via ProteomeXchange.

Title	Interplay between nuclear tau phosphorylation and HSV-1 infection.
Description	In this study, we investigated the effects of HSV-1 infection on tau phosphorylation in human brain cortical organoids. Our findings demonstrate that HSV-1 triggers nuclear accumulation of phosphorylated tau in neurons within the developing cortical plate as well as in neural precursor cells (NPCs) in the ventricular/subventricular-like zones of these differentiating cortical structures. Antiviral treatment effectively inhibited nuclear tau accumulation in both KOS- and 17syn+-infected organoids. Importantly, for the first time we provide evidence of a potential interaction of phosphorylated tau with HSV-1 genome. Furthermore, we ruled out the involvement of the Cyclin-dependent kinase 5 (Cdk5) in the nuclear phosphorylation of tau. Finally, we show that HSV-1 causes a significant alteration in the abundance of components of nuclear speckles and proteins known to be associated with neurodegenerative diseases.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:15:53.369.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD047281
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matthew MacDonald
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-27 08:22:08	ID requested
⏵ 1	2025-05-06 12:15:54	announced

10.1016/j.nbd.2025.106804;

D'Aiuto L, Caldwell JK, Edwards TG, Zhou C, McDonald ML, Di Maio R, Joel WA, Hyde VR, Wallace CT, Watkins SC, Wesesky MA, Shemesh OA, Nimgaonkar VL, Bloom DC, Phosphorylated-tau associates with HSV-1 chromatin and correlates with nuclear speckles decondensation in low-density host chromatin regions. Neurobiol Dis, 206():106804(2025) [pubmed]

10.6019/PXD047281;

submitter keyword: Human, Alzheimers, Herpes Simplex Virus, neurodegenerative diseases, tau

Matthew L. MacDonald
contact affiliation	University of Pittsburgh Department of psychiatry
contact email	mlmacdonald@gmail.com
lab head
Matthew MacDonald
contact affiliation	University of Pittsburgh
contact email	mlmacdonald@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD047281

PRIDE project URI

• PRIDE
  1. PXD047281
     1. Label: PRIDE project
     2. Name: Interplay between nuclear tau phosphorylation and HSV-1 infection.