PXD047230

PXD047230 is an original dataset announced via ProteomeXchange.

Title	Neuropeptidomics of the American Lobster Homarus americanus
Description	The American lobster, Homarus americanus, is not only of considerable economic importance but has also emerged as a pivotal model in neuroscience research. Neuropeptides, an important class of cell-to-cell signaling molecules, play crucial roles in a wide array of physiological and psychological processes. In light of the recently sequenced high-quality draft genome of the American lobster, our study sought to profile the neuropeptidome in this model organism. Employing advanced mass spectrometry techniques alongside functional genomic analysis, we identified 24 neuropeptide precursors and 101 unique mature neuropeptides in Homarus americanus. Intriguingly, 67 of these neuropeptides were discovered for the first time. Our findings offer a comprehensive overview of the peptidomic attributes of the lobster's nervous system and highlight the tissue-specific distribution of these neuropeptides. Collectively, this research not only enriches our understanding of the neural complexities of the American lobster but also sets a foundational basis for future investigations into the functional roles that these peptides play in crustacean species.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:37:29.915.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gaoyuan Lu
SpeciesList	scientific name: Homarus americanus; NCBI TaxID: 6706;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics flex series

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-24 16:27:41	ID requested
1	2024-04-27 10:06:02	announced
⏵ 2	2024-10-22 06:37:30	announced	2024-10-22: Updated project metadata.

10.1021/ACS.JPROTEOME.3C00925;

submitter keyword: American lobster, mass spectrometry, neuropeptide,peptidome

Lingjun Li
contact affiliation	1 School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, United States 2 Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, United States
contact email	lingjun.li@wisc.edu
lab head
Gaoyuan Lu
contact affiliation	University of Wisconsin-Madison
contact email	gaoyuan.lu@wisc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD047230

PRIDE project URI

• PRIDE
  1. PXD047230
     1. Label: PRIDE project
     2. Name: Neuropeptidomics of the American Lobster Homarus americanus