PXD047211

PXD047211 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comprehensive ubiquitomics characterization identify biomarkers of liver cancer subtypes
Description	Hepatocellular carcinoma (HCC) has been widely studied at multi-omics level, but little is known about its specific ubiquitination, a major post-translational modification (PTM). In this study, we performed the ubiquitomics data collected from 85 HCC tumors and 18 adjacent normal tissues (ANTs) to establish the ubiquitomic profiles of HCC and reveal tumor-associated characteristics with prognosis and clinical outcomes. Ubiquitomic based stratification of HCC revealed three subtypes related to different clinical and molecular features, suggesting ubiquitomics have the potential to further understand the relationship between ubiquitination levels of proteins and different molecular and clinical features of HCC patients. XAD1—XAD18 --- HCC adjacent normal tissues XC1—XC85--- HCC tumor tissues
HostingRepository	PRIDE
AnnounceDate	2025-04-07
AnnouncementXML	Submission_2025-04-07_10:28:37.197.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuanming Xie
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-23 19:55:17	ID requested
⏵ 1	2025-04-07 10:28:38	announced

Publication List

10.1097/hep.0000000000001096;
Lin XT, Luo YD, Mao C, Gong Y, Hou Y, Zhang LD, Gu YP, Wu D, Zhang J, Zhang YJ, Tan DH, Xie CM, Integrated ubiquitomics characterization of hepatocellular carcinomas. Hepatology, ():(2024) [pubmed]

10.1097/hep.0000000000001096;

Lin XT, Luo YD, Mao C, Gong Y, Hou Y, Zhang LD, Gu YP, Wu D, Zhang J, Zhang YJ, Tan DH, Xie CM, Integrated ubiquitomics characterization of hepatocellular carcinomas. Hepatology, ():(2024) [pubmed]

Keyword List

submitter keyword: Ubiquitomics
Human
HCC;

submitter keyword: Ubiquitomics

Human

HCC;

Contact List

Chuanming Xie
contact affiliation	Third Military Medical University
contact email	chuanming506@126.com
lab head
Chuanming Xie
contact affiliation	Third Military Medical University
contact email	chuanming506@126.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD047211
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD047211

PRIDE project URI

Repository Record List

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