PXD047207
PXD047207 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Longitudinal plasma proteome profiling reveals the dynamic biomarkers for prediction of cetuximab therapy response in colorectal cancer patients |
| Description | Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab therapy with multi-course treatment, and 90 healthy controls (HCs). COL12A1, THBS2, S100A8, and S100A9 are screened as potential proteins to distinguish CRCs from HCs both in plasma and tissue validation cohorts. We identify the potential biomarkers (RRAS2, MMP8, FBLN1, RPTOR, and IMPDH2) for the initial response prediction. In a longitudinal setting, we identify two clusters with distinct fluctuations and construct the model with high accuracy to predict the longitudinal response, further validated in the independent cohort. This study reveals the heterogeneity of different biomarkers for tumor diagnosis, the initial and longitudinal response prediction respectively in the first course and multi-course cetuximab treatment, may ultimately be useful in monitoring and intervention strategies for CRC. |
| HostingRepository | iProX |
| AnnounceDate | 2023-11-23 |
| AnnouncementXML | Submission_2023-11-23_18:58:55.335.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yan Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF; Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-11-23 18:57:55 | ID requested | |
| ⏵ 1 | 2023-11-23 18:58:55 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Colorectal cancer, Plasma proteome, Cetuximab therapy |
Contact List
| Chen Ding | |
|---|---|
| contact affiliation | Fudan University |
| contact email | chend@fudan.edu.cn |
| lab head | |
| Yan Li | |
| contact affiliation | Fudan University |
| contact email | yanlee2020@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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