PXD047179

PXD047179 is an original dataset announced via ProteomeXchange.

Title	Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma
Description	Uveal melanoma (UM) is the most common intraocular tumor in adults, and its pathogenesis is only partly understood. UM can develop de novo from normal choroidal melanocytes (NCMs) or from pre-existing nevi that stem from NCMs and are thought to harbour UM-initiating mutations, most commonly in GNAQ or GNA11. However, there is a complete lack of commercially available NCM cell lines and no detailed protocol for developing oncogene-mutated CM line (MutCM) to study UM development. The purpose of this study was to establish and characterize premalignant CM models from human donor eyes to recapitulate the cell populations at the origin of UM.
HostingRepository	PRIDE
AnnounceDate	2024-11-25
AnnouncementXML	Submission_2024-11-25_08:49:51.060.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yunxi Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-22 13:54:47	ID requested
⏵ 1	2024-11-25 08:49:51	announced

Dataset with its publication pending

submitter keyword: uveal melanoma, proteomics, primary cell culture,human donor eyes

Julia V. Burnier
contact affiliation	Research Institute of the McGill University Health Centre
contact email	julia.burnier@mcgill.ca
lab head
Yunxi Chen
contact affiliation	Research Institute of the McGill University Health Centre
contact email	yunxi.chen@mail.mcgill.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD047179

PRIDE project URI

• PRIDE
  1. PXD047179
     1. Label: PRIDE project
     2. Name: Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma