PXD047081

PXD047081 is an original dataset announced via ProteomeXchange.

Title	Activity-based protein profiling reveals Hydroxysafflor yellow A binds to malate dehydrogenase 1 against myocardial ischemia reperfusion injury by maintaining mitochondrial functional homeostasis
Description	Hydroxysafflor yellow A (HSYA), a natural product derived from Carthamus tinctorius L., has been approved for the treatment of cardiovascular and cerebrovascular diseases and emerged as an effective therapeutic drug on myocardial ischemia reperfusion (MI/R) injury via mechanisms which are poorly understood. We employed Reductive dimethyl labeling with tandem orthogonal proteolysis-activity-based protein profiling (rdTOP-ABPP) method to reveal the direct binding proteins and site in mitochondrion.
HostingRepository	iProX
AnnounceDate	2023-11-18
AnnouncementXML	Submission_2023-11-19_22:49:33.591.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianye Dai
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	dimethylated residue; oxidation; S-carboxamidomethyl-L-cysteine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-19 22:49:25	ID requested
⏵ 1	2023-11-19 22:49:33	announced

Dataset with its publication pending

submitter keyword: Hydroxysafflor yellow A, Malate dehydrogenase 1, Activity-based protein profiling, Myocardial ischemia reperfusion injury, Energy metabolism

Jianye Dai
contact affiliation	Lanzhou University
contact email	daijy@lzu.edu.cn
lab head
Jianye Dai
contact affiliation	Lanzhou University
contact email	daijy@lzu.edu.cn
dataset submitter

iProX dataset URI