PXD046984

PXD046984 is an original dataset announced via ProteomeXchange.

Title	Loss of the lipid transfer protein STARD7 triggers metabolic reprogramming and an epigenetic-mediated cell cycle arrest in breast cancer
Description	Cancer cells have to constantly adapt their metabolism to support aberrant cell proliferation. However, the functional link between metabolic reprogramming and cell cycle progression remain largely unexplored. Mitochondria rely on the transfer of multiple lipids from the endoplasmic reticulum (ER) to their membranes to be functional. Several mitochondrial-derived metabolites influence cancer cell proliferation by modulating the epigenome. Here we show that the loss of STARD7, a lipid transfer protein whose expression is enhanced in breast cancer, leads to a profound metabolic reprogramming characterized by the increased synthesis of Carnitine derivatives and S-Adenosyl-L-methionine (SAM). Elevated SAM levels causes the accumulation of H3K27 trimethylation, a repressive mark, on many gene promoters coding for candidates involved in cell cycle progression and in the response to oxidative stress. As a result, STARD7 deficiency triggers cell cycle arrest, at least through defective ER?- and EGFR-dependent signaling pathways as well as to autophagy and ciliogenesis. Collectively, our data define STARD7 as a critical candidate involved in cell cycle progression in breast cancer.
HostingRepository	PRIDE
AnnounceDate	2025-09-01
AnnouncementXML	Submission_2025-08-31_16:58:29.728.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alex von Kriegsheim
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-15 03:57:01	ID requested
⏵ 1	2025-08-31 16:58:30	announced

Dondajewska E, Allepuz-Fuster P, Maurizy C, Hego A, Ormenese S, Lion Q, Blomme A, Close P, Lavergne A, Karim L, Thiry M, Nemazanyy I, Krishnankutty R, Marques J, von Kriegsheim A, Henneman NF, Panasyuk G, Shostak K, Chariot A, Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer. Adv Sci (Weinh), 12(31):e03022(2025) [pubmed]

10.1002/advs.202503022;

submitter keyword: metabolism, lipid transfer,cancer

Alain Chariot
contact affiliation	U o Liege
contact email	Alain.Chariot@uliege.be
lab head
Alex von Kriegsheim
contact affiliation	University of Edinburgh
contact email	alex.vonkriegsheim@ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD046984

PRIDE project URI

• PRIDE
  1. PXD046984
     1. Label: PRIDE project
     2. Name: Loss of the lipid transfer protein STARD7 triggers metabolic reprogramming and an epigenetic-mediated cell cycle arrest in breast cancer