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PXD046982

PXD046982 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAffimer reagents as tools to modulate GPVI-ligand interactions
DescriptionWe have isolated Affimers that bind to GPVI and characterized their effect on receptor function. An affimer that binds specifically to dimeric GPVI was identified as a novel tool to detect dimeric GPVI. The binding sites of the different Affimers were mapped using HDX-MS, revealing that they interact with functional regions for regulating collagen binding and dimerization.
HostingRepositoryPRIDE
AnnounceDate2024-10-01
AnnouncementXMLSubmission_2024-10-01_09:37:55.712.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAntonio Calabrese
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-15 03:18:08ID requested
12024-10-01 09:37:56announced
Publication List
Xu RG, Tiede C, Calabrese AN, Cheah LT, Adams TL, Gauer JS, Hindle MS, Webb BA, Yates DM, Slater A, Duval C, Naseem KM, Herr AB, Tomlinson DC, Watson SP, Ari, ë, ns RAS, Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer. Blood Adv, 8(15):3917-3928(2024) [pubmed]
10.1182/bloodadvances.2024012689;
Keyword List
submitter keyword: HDX-MS,GPVI
Contact List
Antonio Calabrese
contact affiliationAstbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
contact emaila.calabrese@leeds.ac.uk
lab head
Antonio Calabrese
contact affiliationSchool of Molecular and Cellular Biology, University of Leeds
contact emaila.calabrese@leeds.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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