PXD046970

PXD046970 is an original dataset announced via ProteomeXchange.

Title	Proteome of Control versus shKDM2B in MDA-MB-231 Cells
Description	Project comparing the proteome between control and knockdown of KDM2B in MDA-MB-231 cell lines. Previous data demonstrated that knockdown of KDM2B induced transcriptional changes in ribosomal and metabolic gene targets and thus TMT proteomics was pursued to compare the protein level changes that occur after knockdown of KDM2B.
HostingRepository	PRIDE
AnnounceDate	2023-11-22
AnnouncementXML	Submission_2023-11-22_04:57:41.913.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vollter Anastas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-14 18:29:35	ID requested
⏵ 1	2023-11-22 04:57:42	announced

10.1016/j.metabol.2023.155719;

Chavdoula E, Anastas V, La Ferlita A, Aldana J, Carota G, Spampinato M, Soysal B, Cosentini I, Parashar S, Sircar A, Nigita G, Sehgal L, Freitas MA, Tsichlis PN, Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4. Metabolism, 150():155719(2024) [pubmed]

submitter keyword: Human, Breast Cancer, TMT proteomics, MDA-MB-231, KDM2B

Philip N.
contact affiliation	Professor and Chair, Department of Cancer Biology and Genetics The Ohio State University College of Medicine Co-Leader, Cancer Biology Program The Ohio State University Comprehensive Cancer Center
contact email	philip.tsichlis@osumc.edu
lab head
Vollter Anastas
contact affiliation	Tufts University School of Medicine
contact email	erianastas@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD046970

PRIDE project URI

• PRIDE
  1. PXD046970
     1. Label: PRIDE project
     2. Name: Proteome of Control versus shKDM2B in MDA-MB-231 Cells