PXD046930

PXD046930 is an original dataset announced via ProteomeXchange.

Title	iTRAQ-based identification of oral cancer progression-related proteins with tumor tissues from oral cancer patients and patient-derived xenograft mouse models
Description	In Taiwan, oral cancer has been the fourth leading cause of cancer-related deaths in men for at least a decade. Clinical statistics show that approximately 95% of all oral cancer cases are oral cavity squamous cell carcinoma (OSCC). Patients diagnosed with advanced-stage OSCC often present with cervical lymphatic or distant metastasis of cancer cells. The metastasis of OSCC results in a high mortality rate of the disease, indicating that the identification of proteins involved in the progression and/or metastasis of OSCC is important to develop novel strategies for OSCC treatments. To this end, five patient-derived xenograft (PDX) mouse models of OSCC have been established for understanding OSCC microenvironment and progression. Using isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry, proteins in the tumor tissues of five OSCC patients and five PDX mouse models have been quantitatively profiled. Furthermore, we have determined gene expression profiles of the cancer tissues from four OSCC patients and four PDX mice using the RNA-Seq analyses. Candidate proteins consistently dysregulated in tumor tissues of primary OSCC and PDX mouse models would be selected for further evaluation as potential progression-related proteins and therapeutic targets of OSCC.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:47:42.756.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chih-Ching Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ4plex-116 reporter+balance reagent acylated residue; methylthiolated residue; monohydroxylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-13 22:42:18	ID requested
⏵ 1	2025-05-06 12:47:43	announced

10.1186/s11658-024-00651-0;

Chan XY, Chang KP, Yang CY, Liu CR, Hung CM, Huang CC, Liu HP, Wu CC, -catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis. Cell Mol Biol Lett, 29(1):136(2024) [pubmed]

ProteomeXchange project tag: Human Proteome Project

submitter keyword: patient-derived xenografts, proteomics, tumor tissue, iTRAQ,oral cavity squamous cell carcinoma

Chih-Ching Wu
contact affiliation	Department of Medical Biotechnology and Laboratory Science College of Medicine, Chang Gung University, Taoyuan, Taiwan
contact email	luckywu@mail.cgu.edu.tw
lab head
Chih-Ching Wu
contact affiliation	Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University
contact email	luckywu@mail.cgu.edu.tw
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD046930

PRIDE project URI

• PRIDE
  1. PXD046930
     1. Label: PRIDE project
     2. Name: iTRAQ-based identification of oral cancer progression-related proteins with tumor tissues from oral cancer patients and patient-derived xenograft mouse models