PXD046908

PXD046908 is an original dataset announced via ProteomeXchange.

Title	SWATH-MS Proteomic Analysis Identifies C/EBPβ Suppression by RUNX1-ETO as a Potential Mediator of Block in Differentiation
Description	Acute myeloid leukemia (AML) is a heterogenous disease with multiple morphological, immunophenotypic and genetic features. The t(8;21), which results in the expression of RUNX1-ETO (aka AML1-ETO), is accountable for 12% of AML cases (1). Previously, this fusion protein has been shown to block hematopoietic development of normal human hematopoietic stem and progenitor cells (HSPC), as well as promoting the cells’ self-renewal potential (2,3). Even though several studies have determined the transcriptomic changes observed in cells expressing RUNX1-ETO, there is a paucity of studies quantitating proteomic changes. Given that transcriptional regulation is likely mediated by changes in transcription factor (TF) expression, I hypothesize that RUNX1-ETO leads to TF dysregulation, of which critical components might dictate differentiation blockage.
HostingRepository	PRIDE
AnnounceDate	2026-07-06
AnnouncementXML	Submission_2026-07-06_02:30:03.889.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bethany Geary
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-13 09:11:22	ID requested
⏵ 1	2026-07-06 02:30:04	announced

10.1016/J.BNEO.2026.100259;

submitter keyword: RUNX1-ETO,AML,SWATH,DIA

Bethany Geary
contact affiliation	UK Dementia Research Institute University of Dundee
contact email	BGeary001@dundee.ac.uk
lab head
Bethany Geary
contact affiliation	University of Dundee
contact email	bgeary001@dundee.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD046908
     1. Label: PRIDE project
     2. Name: SWATH-MS Proteomic Analysis Identifies C/EBPβ Suppression by RUNX1-ETO as a Potential Mediator of Block in Differentiation