PXD046900 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Temporal Quantitative Proteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells During All-trans Retinoic Acid-Induced Neuronal Differentiation |
Description | The human neuroblastoma cell lines SH-SY5Y and IMR-32 can be differentiated into neuron-like phenotypes through treatment with all-trans retinoic acid (ATRA). After differentiation, these cell lines are extensively utilized as in vitro models to study various aspects of neuronal cell biology. However, temporal and quantitative profiling of the proteome and phosphoproteome of SH-SY5Y and IMR-32 cells throughout ATRA-induced differentiation has been limited. Here, we performed relative quantification of the proteomes of SH-SY5Y and IMR-32 cells at multiple time points during ATRA-induced differentiation. The data presented serve as a valuable resource for investigating temporal protein and phosphoprotein abundance changes in SH-SY5Y and IMR-32 cells during ATRA-induced differentiation. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-24 |
AnnouncementXML | Submission_2024-01-23_23:13:06.198.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Thomas.C.N. LEUNG |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; methylthiolated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-13 05:40:00 | ID requested | |
⏵ 1 | 2024-01-23 23:13:07 | announced | |
Publication List
Leung TCN, Lu SN, Chu CN, Lee J, Liu X, Ngai SM, -Retinoic Acid-Induced Neuronal Differentiation. Int J Mol Sci, 25(2):(2024) [pubmed] |
10.3390/ijms25021047; |
Keyword List
submitter keyword: SH-SY5Y, IMR-32, Neuronal Differentiation, TMT, Proteomics |
Contact List
Thomas Chun Ning LEUNG |
contact affiliation | School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China |
contact email | cnleung0509@gmail.com |
lab head | |
Thomas.C.N. LEUNG |
contact affiliation | School of Life Sciences, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong |
contact email | cnleung0509@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046900
- Label: PRIDE project
- Name: Temporal Quantitative Proteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells During All-trans Retinoic Acid-Induced Neuronal Differentiation