PXD046876

PXD046876 is an original dataset announced via ProteomeXchange.

Title	¬¬¬Seabirds in crisis: plastic ingestion induces proteomic signatures of multi-organ failure and neurodegeneration
Description	Understanding plastics’ harmful impacts has been hampered by the application of overly simplistic tools, mostly focusing on a single response variable which limits our ability to detect changes in wildlife health. Adopting a data-driven, proteomics approach, we assessed changes in 745 proteins in a non-model organism with differing levels of plastic exposure. In high plastic impacted seabirds, we observed a range of negative health consequences: intracellular components that should not be found in the blood were frequently detected, indicative of cell lysis. There was significant evidence of neurodegeneration, and secreted proteins were less abundant, indicating the kidney and particularly the liver are not functioning as normal. The proteomic signatures reflect the effects of plastic distal to the site of exposure (i.e., the stomach) demonstrating plastic shedding and leachate toxicity in the plasma. Notably, metrics commonly used to assess body condition do not provide an accurate description of health or plastic impaction.
HostingRepository	PRIDE
AnnounceDate	2025-03-27
AnnouncementXML	Submission_2025-03-26_22:22:23.469.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Richard Wilson
SpeciesList	scientific name: Ardenna carneipes; NCBI TaxID: 1934105;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-12 17:53:55	ID requested
⏵ 1	2025-03-26 22:22:24	announced

de Jersey AM, Lavers JL, Bond AL, Wilson R, Zosky GR, Rivers-Auty J, Seabirds in crisis: Plastic ingestion induces proteomic signatures of multiorgan failure and neurodegeneration. Sci Adv, 11(11):eads0834(2025) [pubmed]

10.1126/sciadv.ads0834;

submitter keyword: shearwater, wildlife, proteomics,Microplastics

Dr Richard Wilson
contact affiliation	Proteomics facility, Central Science Laboratory, University of Tasmania
contact email	richard.wilson@utas.edu.au
lab head
Richard Wilson
contact affiliation	University of Tasmania
contact email	richard.wilson@utas.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD046876

PRIDE project URI

• PRIDE
  1. PXD046876
     1. Label: PRIDE project
     2. Name: ¬¬¬Seabirds in crisis: plastic ingestion induces proteomic signatures of multi-organ failure and neurodegeneration