PXD046854 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Senolytic-Facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea |
Description | Rationale: Obstructive sleep apnea (OSA) is a highly prevalent condition that is associated with accelerated biological aging and multiple end-organ morbidities. Current treatments, such as continuous positive airway pressure (CPAP), have shown limited cognitive, metabolic, and cardiovascular beneficial outcomes despite adherence. Thus, adjunct therapies aiming to reduce OSA burden, such as senolytics, could improve OSA outcomes. Objectives: To assess if targeting senescence in addition to partial normoxia mimicking “good” CPAP adherence can improve physiological outcomes in mice exposed to chronic intermittent hypoxia (IH). Methods: We compared the effects of 6 weeks therapy with either partial normoxic recovery alone or combined with the senolytic Navitoclax (NAV) after 16 weeks of IH exposures, a hallmark of OSA, on multi-phenotypic cardiometabolic and neurocognitive parameters. Results: Our findings indicate that only when combined with NAV, partial normoxic recovery significantly improved wakefulness (sleep in the dark phase: 34 ± 4% vs. 24 ± 3%, p < 0.01), cognition (Preference score: 51 ± 19% vs. 70 ± 11%, p < 0.05), coronary artery function (response to acetylcholine (vasodilation): 56 ± 13% vs. 72 ± 10%, p < 0.001), glucose, and lipid metabolism, and reduced intestinal permeability and senescence in multiple organs. Conclusions: These findings indicate that the reversibility of end-organ morbidities induced by OSA are not only contingent on restoration of normal oxygenation patterns and can be further enhanced by targeting other OSA-mediated detrimental cellular processes, such as accelerated senescence. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-06 |
AnnouncementXML | Submission_2025-05-06_12:08:28.849.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Brian Mooney |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | timsTOF Pro 2 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-10 12:15:09 | ID requested | |
⏵ 1 | 2025-05-06 12:08:29 | announced | |
Publication List
10.1164/rccm.202306-1101oc; |
Badran M, Puech C, Khalyfa A, Cortese R, Cataldo K, Qiao Z, Gozal D, Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea. Am J Respir Crit Care Med, 209(8):1001-1012(2024) [pubmed] |
Keyword List
submitter keyword: normoxia,sleep apnea, intermittent hypoxia, senescence |
Contact List
Abdelnaby Khalyfa |
contact affiliation | Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, United States |
contact email | khalyfaa@missouri.edu |
lab head | |
Brian Mooney |
contact affiliation | University of Missouri, Columbia |
contact email | mooneyb@missouri.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046854
- Label: PRIDE project
- Name: Senolytic-Facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea