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PXD046848

PXD046848 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEjaculate samples for male infertility screening
DescriptionThe problem of the male reproductive system has both medical and social importance. It is highlighted that spermatozoa or seminal plasma are suitable samples for proteomic analysis of the male reproductive system. We suggested that the ejaculate could serve as one of the analytic specimens to determine fertility, which obtainable with relative ease and which contains many proteins. Moreover, the testis-specific proteins could form the basis of protein panel for detecting disorders associated with male infertility. The current study aimed to examine the ejaculate proteome compared to the spermatozoa and seminal plasma proteomes to determine a panel of proteins that can be used to assess sperm quality. Our results showed that the ejaculate represented a productive source for understanding the male reproductive physiology and could serve as a potential origin for the identification of novel protein biomarkers related to spermatozoa function in infertile. We believe that proteomic analysis based on testis-specific proteins of ejaculate along with spermatozoa (or even instead) can be useful for distinguishing the fertile, sub fertile, and infertile men.
HostingRepositoryPRIDE
AnnounceDate2024-05-23
AnnouncementXMLSubmission_2024-05-22_23:48:51.311.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTimur Shkrigunov
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-10 07:16:16ID requested
12024-05-22 23:48:52announced
Publication List
Shkrigunov T, Zgoda V, Klimenko P, Kozlova A, Klimenko M, Lisitsa A, Kurtser M, Petushkova N, The Application of Ejaculate-Based Shotgun Proteomics for Male Infertility Screening. Biomedicines, 12(1):(2023) [pubmed]
10.3390/biomedicines12010049;
Keyword List
ProteomeXchange project tag: Human Proteome Project
submitter keyword: proteomic analysis,Male infertility, testis-specific proteins, ejaculate, spermatozoa
Contact List
Andrey Lisitsa
contact affiliationLaboratory of Protein Biochemistry and Pathology, Institute of Biomedical Chemistry, Moscow, Russia
contact emaillisitsa058@gmail.com
lab head
Timur Shkrigunov
contact affiliationInstitute of Biomedical Chemistry, Moscow, Russia
contact emailshkrigunov05@mail.ru
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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