PXD046848

PXD046848 is an original dataset announced via ProteomeXchange.

Title	Ejaculate samples for male infertility screening
Description	The problem of the male reproductive system has both medical and social importance. It is highlighted that spermatozoa or seminal plasma are suitable samples for proteomic analysis of the male reproductive system. We suggested that the ejaculate could serve as one of the analytic specimens to determine fertility, which obtainable with relative ease and which contains many proteins. Moreover, the testis-specific proteins could form the basis of protein panel for detecting disorders associated with male infertility. The current study aimed to examine the ejaculate proteome compared to the spermatozoa and seminal plasma proteomes to determine a panel of proteins that can be used to assess sperm quality. Our results showed that the ejaculate represented a productive source for understanding the male reproductive physiology and could serve as a potential origin for the identification of novel protein biomarkers related to spermatozoa function in infertile. We believe that proteomic analysis based on testis-specific proteins of ejaculate along with spermatozoa (or even instead) can be useful for distinguishing the fertile, sub fertile, and infertile men.
HostingRepository	PRIDE
AnnounceDate	2024-05-23
AnnouncementXML	Submission_2024-05-22_23:48:51.311.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Timur Shkrigunov
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-10 07:16:16	ID requested
⏵ 1	2024-05-22 23:48:52	announced

Shkrigunov T, Zgoda V, Klimenko P, Kozlova A, Klimenko M, Lisitsa A, Kurtser M, Petushkova N, The Application of Ejaculate-Based Shotgun Proteomics for Male Infertility Screening. Biomedicines, 12(1):(2023) [pubmed]

10.3390/biomedicines12010049;

ProteomeXchange project tag: Human Proteome Project

submitter keyword: proteomic analysis,Male infertility, testis-specific proteins, ejaculate, spermatozoa

Andrey Lisitsa
contact affiliation	Laboratory of Protein Biochemistry and Pathology, Institute of Biomedical Chemistry, Moscow, Russia
contact email	lisitsa058@gmail.com
lab head
Timur Shkrigunov
contact affiliation	Institute of Biomedical Chemistry, Moscow, Russia
contact email	shkrigunov05@mail.ru
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD046848

PRIDE project URI

• PRIDE
  1. PXD046848
     1. Label: PRIDE project
     2. Name: Ejaculate samples for male infertility screening