PXD046848 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Ejaculate samples for male infertility screening |
Description | The problem of the male reproductive system has both medical and social importance. It is highlighted that spermatozoa or seminal plasma are suitable samples for proteomic analysis of the male reproductive system. We suggested that the ejaculate could serve as one of the analytic specimens to determine fertility, which obtainable with relative ease and which contains many proteins. Moreover, the testis-specific proteins could form the basis of protein panel for detecting disorders associated with male infertility. The current study aimed to examine the ejaculate proteome compared to the spermatozoa and seminal plasma proteomes to determine a panel of proteins that can be used to assess sperm quality. Our results showed that the ejaculate represented a productive source for understanding the male reproductive physiology and could serve as a potential origin for the identification of novel protein biomarkers related to spermatozoa function in infertile. We believe that proteomic analysis based on testis-specific proteins of ejaculate along with spermatozoa (or even instead) can be useful for distinguishing the fertile, sub fertile, and infertile men. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-23 |
AnnouncementXML | Submission_2024-05-22_23:48:51.311.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Timur Shkrigunov |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-10 07:16:16 | ID requested | |
⏵ 1 | 2024-05-22 23:48:52 | announced | |
Publication List
Shkrigunov T, Zgoda V, Klimenko P, Kozlova A, Klimenko M, Lisitsa A, Kurtser M, Petushkova N, The Application of Ejaculate-Based Shotgun Proteomics for Male Infertility Screening. Biomedicines, 12(1):(2023) [pubmed] |
10.3390/biomedicines12010049; |
Keyword List
ProteomeXchange project tag: Human Proteome Project |
submitter keyword: proteomic analysis,Male infertility, testis-specific proteins, ejaculate, spermatozoa |
Contact List
Andrey Lisitsa |
contact affiliation | Laboratory of Protein Biochemistry and Pathology, Institute of Biomedical Chemistry, Moscow, Russia |
contact email | lisitsa058@gmail.com |
lab head | |
Timur Shkrigunov |
contact affiliation | Institute of Biomedical Chemistry, Moscow, Russia |
contact email | shkrigunov05@mail.ru |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD046848 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046848
- Label: PRIDE project
- Name: Ejaculate samples for male infertility screening