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PXD046815

PXD046815 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics-based identification of potential therapeutic targets of artesunate in a lupus nephritis MRL/lpr mouse model
DescriptionA total of 6527.0 proteins were identified in the First Affiliated Hospital of Sun Yat sen University, of which 5732.0 proteins contained quantitative information. If we take 1.5 times as the differential expression change threshold and t-test p-value < 0.05 as the significance threshold, we found that 440 proteins were up-regulated and 339 proteins were down regulated in the MRL vs normal comparison group. Based on the above data, we performed systematic bioinformatics analysis (protein function annotation) on all identified proteins, and performed functional classification, functional enrichment and cluster analysis based on functional enrichment on all differentially expressed proteins. Based on the above information, it provides a reference direction for downstream proteome based in-depth research.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:42:40.759.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmittercong wang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-09 03:51:55ID requested
12024-05-24 02:48:38announced
22024-10-22 06:42:48announced2024-10-22: Updated project metadata.
Publication List
Wen Q, Wang C, Chen D, Luo N, Fan J, Zhou Y, Yu X, Chen W, Proteomics-Based Identification of Potential Therapeutic Targets of Artesunate in a Lupus Nephritis MRL/lpr Mouse Model. J Proteome Res, 23(4):1150-1162(2024) [pubmed]
10.1021/acs.jproteome.3c00558;
Keyword List
submitter keyword: Lupus nephritis;Artesunate;TMT-based quantitative proteomics
Contact List
Wen Qiong
contact affiliationThe First Affiliated Hospital of Sun Yat sen university
contact emailwenqiong80@139.com
lab head
cong wang
contact affiliationThe First Affiliated Hospital of Sun Yat sen University
contact email1069943118@qq.com
dataset submitter
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Dataset FTP location
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Repository Record List
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