PXD046815

PXD046815 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomics-based identification of potential therapeutic targets of artesunate in a lupus nephritis MRL/lpr mouse model
Description	A total of 6527.0 proteins were identified in the First Affiliated Hospital of Sun Yat sen University, of which 5732.0 proteins contained quantitative information. If we take 1.5 times as the differential expression change threshold and t-test p-value < 0.05 as the significance threshold, we found that 440 proteins were up-regulated and 339 proteins were down regulated in the MRL vs normal comparison group. Based on the above data, we performed systematic bioinformatics analysis (protein function annotation) on all identified proteins, and performed functional classification, functional enrichment and cluster analysis based on functional enrichment on all differentially expressed proteins. Based on the above information, it provides a reference direction for downstream proteome based in-depth research.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:42:40.759.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	cong wang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-09 03:51:55	ID requested
1	2024-05-24 02:48:38	announced
⏵ 2	2024-10-22 06:42:48	announced	2024-10-22: Updated project metadata.

Publication List

Wen Q, Wang C, Chen D, Luo N, Fan J, Zhou Y, Yu X, Chen W, Proteomics-Based Identification of Potential Therapeutic Targets of Artesunate in a Lupus Nephritis MRL/lpr Mouse Model. J Proteome Res, 23(4):1150-1162(2024) [pubmed]
10.1021/acs.jproteome.3c00558;

Wen Q, Wang C, Chen D, Luo N, Fan J, Zhou Y, Yu X, Chen W, Proteomics-Based Identification of Potential Therapeutic Targets of Artesunate in a Lupus Nephritis MRL/lpr Mouse Model. J Proteome Res, 23(4):1150-1162(2024) [pubmed]

10.1021/acs.jproteome.3c00558;

Keyword List

submitter keyword: Lupus nephritis;Artesunate;TMT-based quantitative proteomics

submitter keyword: Lupus nephritis;Artesunate;TMT-based quantitative proteomics

Contact List

Wen Qiong
contact affiliation	The First Affiliated Hospital of Sun Yat sen university
contact email	wenqiong80@139.com
lab head
cong wang
contact affiliation	The First Affiliated Hospital of Sun Yat sen University
contact email	1069943118@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD046815
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD046815

PRIDE project URI

Repository Record List

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