PXD046815 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics-based identification of potential therapeutic targets of artesunate in a lupus nephritis MRL/lpr mouse model |
Description | A total of 6527.0 proteins were identified in the First Affiliated Hospital of Sun Yat sen University, of which 5732.0 proteins contained quantitative information. If we take 1.5 times as the differential expression change threshold and t-test p-value < 0.05 as the significance threshold, we found that 440 proteins were up-regulated and 339 proteins were down regulated in the MRL vs normal comparison group. Based on the above data, we performed systematic bioinformatics analysis (protein function annotation) on all identified proteins, and performed functional classification, functional enrichment and cluster analysis based on functional enrichment on all differentially expressed proteins. Based on the above information, it provides a reference direction for downstream proteome based in-depth research. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:42:40.759.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | cong wang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-09 03:51:55 | ID requested | |
1 | 2024-05-24 02:48:38 | announced | |
⏵ 2 | 2024-10-22 06:42:48 | announced | 2024-10-22: Updated project metadata. |
Publication List
Wen Q, Wang C, Chen D, Luo N, Fan J, Zhou Y, Yu X, Chen W, Proteomics-Based Identification of Potential Therapeutic Targets of Artesunate in a Lupus Nephritis MRL/lpr Mouse Model. J Proteome Res, 23(4):1150-1162(2024) [pubmed] |
10.1021/acs.jproteome.3c00558; |
Keyword List
submitter keyword: Lupus nephritis;Artesunate;TMT-based quantitative proteomics |
Contact List
Wen Qiong |
contact affiliation | The First Affiliated Hospital of Sun Yat sen university |
contact email | wenqiong80@139.com |
lab head | |
cong wang |
contact affiliation | The First Affiliated Hospital of Sun Yat sen University |
contact email | 1069943118@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD046815 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046815
- Label: PRIDE project
- Name: Proteomics-based identification of potential therapeutic targets of artesunate in a lupus nephritis MRL/lpr mouse model