PXD046809

PXD046809 is an original dataset announced via ProteomeXchange.

Title	ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.
Description	Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of-function variants of ASGR1 are associated with a favorable metabolic profile and reduced incidence of cardiovascular diseases. The molecular mechanisms by which ASGR1 could affect the onset of metabolic syndrome and obesity are unclear. Therefore, here we investigated the contribution of ASGR1 in the development of metabolic syndrome and obesity.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:27:58.492.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Monika Svecla
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-09 01:41:00	ID requested
1	2024-01-29 02:48:01	announced
⏵ 2	2024-10-22 06:27:58	announced	2024-10-22: Updated project metadata.

10.1186/S12933-023-02099-6;

submitter keyword: Adipose tissue, Liver,ASGR1, Shotgun proteomics

Giuseppe Danilo Norata
contact affiliation	Professor of Pharmacology, Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti", University of Milan
contact email	danilo.norata@unimi.it
lab head
Monika Svecla
contact affiliation	University of Milan
contact email	monika.svecla@unimi.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD046809

PRIDE project URI

• PRIDE
  1. PXD046809
     1. Label: PRIDE project
     2. Name: ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.