PXD046809 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity. |
Description | Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of-function variants of ASGR1 are associated with a favorable metabolic profile and reduced incidence of cardiovascular diseases. The molecular mechanisms by which ASGR1 could affect the onset of metabolic syndrome and obesity are unclear. Therefore, here we investigated the contribution of ASGR1 in the development of metabolic syndrome and obesity. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:27:58.492.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Monika Svecla |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-09 01:41:00 | ID requested | |
1 | 2024-01-29 02:48:01 | announced | |
⏵ 2 | 2024-10-22 06:27:58 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Adipose tissue, Liver,ASGR1, Shotgun proteomics |
Contact List
Giuseppe Danilo Norata |
contact affiliation | Professor of Pharmacology, Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti", University of Milan |
contact email | danilo.norata@unimi.it |
lab head | |
Monika Svecla |
contact affiliation | University of Milan |
contact email | monika.svecla@unimi.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046809
- Label: PRIDE project
- Name: ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.