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PXD046807

PXD046807 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSuper-SILAC-based quantitative proteomic analysis of lung adenocarcinoma associated with stage and EGFR gene status
DescriptionLung adenocarcinoma (LUAD) is one of the most common causes of cancer death worldwide. Epidermal growth factor receptor (EGFR) mutations (MT) frequently target LUAD patients in Eastern Asia. EGFR tyrosine kinase inhibitors were developed to benefit LUAD patients harboring EGFR-activating MT. Unfortunately, biomarkers for early diagnosis and targeted therapy for patients with wild-type (WT) EGFR are currently lacking. Based on the super-SILAC, this study established a LUAD proteomics data set related to stage and EGFR status. Specifically, proteins obtained from three locally established LUAD cell lines were pooled with LUAD tissues from women, never smokers, different histological stages (early and late), and EGFR status (wild-type and mutant) to establish a quantitative proteome data set. We integrated genomic datasets and proteomic resources to select marker candidates for further characterization via immunohistochemistry and ELISA assays. The biological significance of marker candidates was examined using cell lines. This study provides new insights into the diagnosis and tumorigenesis of LUAD with EGFR-WT.
HostingRepositoryPRIDE
AnnounceDate2025-06-05
AnnouncementXMLSubmission_2025-06-05_06:25:29.715.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChia-Jung Yu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-09 01:15:52ID requested
12025-06-05 06:25:30announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: lung adenocarcinoma, tissue proteome, super-SILAC, EGFR, cancer stage
Contact List
Chia-Jung Yu
contact affiliationDepartment of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
contact emailyucj1124@mail.cgu.edu.tw
lab head
Chia-Jung Yu
contact affiliationDepartment of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
contact emailyucj1124@mail.cgu.edu.tw
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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