PXD046801

PXD046801 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis of Survival Motor Neuron (SMN) missense mutants in Drosophila
Description	Spinal Muscular Atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the Survival Motor Neuron (SMN) protein. SMA presents across broad spectrum of disease severity. Unfortunately, vertebrate models of intermediate SMA have been difficult to generate and are thus unable to address key aspects of disease etiology. To address these issues, we developed a Drosophila model system that recapitulates the full range of SMA severity, allowing studies of pre-onset biology as well as late-stage disease processes. In this study, TMT-based quantitative proteomic profiling was performed on mild and intermediate Drosophila models of SMA to elucidate proteins and pathways that contribute to the disease. Using this approach, we elaborated a role for the SMN complex in the regulation of innate immune signaling.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:35:54.706.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Herring
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-08 18:12:56	ID requested
1	2024-04-11 08:16:57	announced
⏵ 2	2024-10-22 06:35:55	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: innate immunity,Spinal Muscular Atrophy (SMA), drosophila

Greg Matera
contact affiliation	Department of Biology, The University of North Carolina at Chapel Hill
contact email	matera@unc.edu
lab head
Laura Herring
contact affiliation	UNC-Chapel Hill
contact email	laura_herring@med.unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD046801

PRIDE project URI

• PRIDE
  1. PXD046801
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analysis of Survival Motor Neuron (SMN) missense mutants in Drosophila