PXD046780

PXD046780 is an original dataset announced via ProteomeXchange.

Title	Identification of dysregulated proteins in primary and relapsed oral cancer tissues with iTRAQ-based mass spectrometry
Description	Oral cancer is the sixth leading cause of the cancer-related mortality in Taiwan. More than 90% of oral cancers are oral cavity squamous cell carcinomas (OSCCs). The high mortality rate of OSCC is ascribed to metastasis and local regional relapse of cancer cells, suggesting that identification of proteins involved in migration and chemoresistance of OSCC cells can facilitate development of useful treatment approaches for OSCC. To identify novel targets for improvement of OSCC therapy, we have comparatively profiled the proteomes of primary and relapsed OSCC tissues with iTRAQ-based mass spectrometry. Gene expression of proteins dysregulated in OSCC tissues was further surveyed with the cancer genome atlas (TCGA) database. With the analysis, we have identified proteins differentially expressed in the primary and/or relapsed OSCC tissues. Proteins up-regulated in recurrent OSCC and associated with OSCC survival have been selected for evaluation as potential therapeutic targets of relapsed OSCC.
HostingRepository	PRIDE
AnnounceDate	2025-06-04
AnnouncementXML	Submission_2025-06-03_20:27:25.151.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chih-Ching Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ4plex-116 reporter+balance reagent acylated residue; methylthiolated residue; monohydroxylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-08 04:03:57	ID requested
⏵ 1	2025-06-03 20:27:26	announced

10.1186/s11658-024-00651-0;

Chan XY, Chang KP, Yang CY, Liu CR, Hung CM, Huang CC, Liu HP, Wu CC, -catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis. Cell Mol Biol Lett, 29(1):136(2024) [pubmed]

ProteomeXchange project tag: Human Proteome Project

submitter keyword: proteomics, tumor tissue, iTRAQ,oral cavity squamous cell carcinoma, relapse

Chih-Ching Wu
contact affiliation	Department of Medical Biotechnology and Laboratory Science College of Medicine, Chang Gung University, Taoyuan, Taiwan
contact email	luckywu@mail.cgu.edu.tw
lab head
Chih-Ching Wu
contact affiliation	Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University
contact email	luckywu@mail.cgu.edu.tw
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD046780

PRIDE project URI

• PRIDE
  1. PXD046780
     1. Label: PRIDE project
     2. Name: Identification of dysregulated proteins in primary and relapsed oral cancer tissues with iTRAQ-based mass spectrometry