PXD046768 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Intensive lifestyle intervention modulates white adipose glycolipid metabolism via protein acetylation associated with Ep300 |
| Description | The homeostatic regulation of white adipose tissue (WAT) is crucial for maintain energy and metabolism balance. Plenty of clinical trials proved that intensive lifestyle intervention (ILI) improved fat accumulation in patients with obesity. Yet the underlying acetylated regulations of WAT during ILI remain incompletely understood. Here, we build a model to simulate this condition and use multi-omics data from WAT to depict the complicated regulation patterns. The results showed non-histones acetylation were mainly involved in glycolipid metabolism centered on acetyl-CoA. A novel site on histones, H3K36ac, showed a relationship with ILI. Based on the association between Ep300 and process of ILI after DIO, a localized lentivirus designed to suppress Ep300 to loss body weight showed an obvious weight reduction and alleviate dyslipidemia effect. Overall, this study reveals the intricacies of acetylation response to ILI and provide novel sights on finding Ep300 lentivirus as a potential therapeutic strategy of obesity. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-02 |
| AnnouncementXML | Submission_2026-03-01_16:50:25.085.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shan Wang |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-11-07 23:36:54 | ID requested | |
| ⏵ 1 | 2026-03-01 16:50:26 | announced | |
Publication List
| 10.1186/s12964-026-02725-2; |
| Wu H, Lin Y, Sun X, Zhang T, Wang H, Zeng Y, Li Y, Wang S, Shi L, Ep300-mediated acetylation plasticity in the acetyl-CoA metabolic network drives the protective role of intensive lifestyle intervention in visceral white adipose tissue. Cell Commun Signal, 24(1):(2026) [pubmed] |
Keyword List
| ProteomeXchange project tag: Human Proteome Project |
| submitter keyword: white adipose tissue |
| acetylation modification |
| obesity |
| intensive lifestyle intervention |
| Ep300 |
Contact List
| Wang Shan, Shi Lin, Wu Haojie |
|---|
| contact affiliation | Capital institute of Pediatrics. |
| contact email | wsaquarius@163.com |
| lab head | |
| Shan Wang |
|---|
| contact affiliation | Capital Institute of Pediatrics, Beijing, China |
| contact email | wsaquarius@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046768
- Label: PRIDE project
- Name: Intensive lifestyle intervention modulates white adipose glycolipid metabolism via protein acetylation associated with Ep300
