PXD046741

PXD046741 is an original dataset announced via ProteomeXchange.

Title	LC-MS of rabies virus glycoproteins in human cells
Description	Rabies virus (RABV), causes a fatal encephalitis disease contributing to an estimated annual death toll of 40 000–70 000 people worldwide. Without effective therapeutic treatment, RABV has a mortality rate approaching 100%. However, it remains unclear how RABV hijack cellular factors to subvert antiviral defenses and enable virus replication. As interactions with these proteins are critical for viral infection and pathogenesis, small molecules or biologics therapies targeting these interfaces may serve as potential antiviral agents. In this study, to better understand how RABV G protein rewire the host cell, we generated a different strains RABV G proteins-human protein interaction map.
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-24_16:03:32.065.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuelan zhang
SpeciesList	scientific name: Lyssavirus rabies; NCBI TaxID: NCBITaxon:11292; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-07 06:28:44	ID requested
⏵ 1	2025-08-24 16:03:32	announced

10.1080/15548627.2024.2390814;

Zhang Y, Zhang X, Yang X, Lv L, Wang Q, Zeng S, Zhang Z, Dorf M, Li S, Zhao L, Fu B, AP3B1 facilitates PDIA3/ERP57 function to regulate rabies virus glycoprotein selective degradation and viral entry. Autophagy, 20(12):2785-2803(2024) [pubmed]

submitter keyword: Human, rabies virus, AS-MS, glycoprotein

Bishi Fu
contact affiliation	Frontiers Science Center for Immunology and Metabolism, Medical Research Institute, Whuhan University Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071
contact email	bishi_fu@whu.edu.cn
lab head
Yuelan zhang
contact affiliation	86+13678941152
contact email	zhangyl0311@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD046741

PRIDE project URI

• PRIDE
  1. PXD046741
     1. Label: PRIDE project
     2. Name: LC-MS of rabies virus glycoproteins in human cells