PXD046733

PXD046733 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of the RNF12/RLIM proximal proteome
Description	RNF12/RLIM is an E3 ubiquitin ligase that plays key developmental roles and is genetically disrupted in the neurodevelopmental disorder Tonne-Kalscheuer syndrome. RNF12/RLIM regulates X-chromosome inactivation and controls the expression of neural and gametogenesis related genes. To better understand how RNF12/RLIM performs these transcription-related functions, we performed a TurboID proximity ligation experiment to identify RNF12/RLIM proximal proteins in mouse embryonic stem cells treated with DMSO or MG132. This knowledge will increase our understanding of how this protein controls developmental gene expression and how disruption of these pathways drives disease.
HostingRepository	PRIDE
AnnounceDate	2024-01-09
AnnouncementXML	Submission_2024-01-09_03:05:47.338.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD046733
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Renata Soares
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-07 01:51:52	ID requested
⏵ 1	2024-01-09 03:05:47	announced

Publication List

10.6019/PXD046733;

10.6019/PXD046733;

Keyword List

submitter keyword: E3 ubiquitin ligase
RNF12/RLIM
embryonic stem cells
protein ubiquitylation
TurboID chromatin
transcription

submitter keyword: E3 ubiquitin ligase

RNF12/RLIM

embryonic stem cells

protein ubiquitylation

TurboID chromatin

transcription

Contact List

Greg Findlay
contact affiliation	MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
contact email	g.m.findlay@dundee.ac.uk
lab head
Renata Soares
contact affiliation	MRC-PPU, University of Dundee
contact email	r.filipesoares@dundee.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD046733
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD046733

PRIDE project URI

Repository Record List

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