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PXD046712

PXD046712 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleB-Cell-based Therapy Controls Glioblastoma Growth by Producing Antibodies that Inhibit Tumor Invasion and Migration
DescriptionGlioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor with limited therapeutic options and poor prognosis. Despite current treatments, the invasive nature of GBM often leads to recurrence. A promising alternative strategy is to harness the immune system's potential against tumor cells. Our previous data showed a B-cell-based vaccine, BVax, can provide a promising therapeutic potential for GBM. In this study, we aim to characterize the antigenic reactivity of BVax-derived antibodies and evaluate their therapeutic potential. We performed immunoproteomics and functional assays in murine models and human GBM patient samples.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:57:56.828.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSi Wang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-06 17:39:18ID requested
12024-09-10 14:21:56announced
22024-10-22 06:57:57announced2024-10-22: Updated project metadata.
Publication List
Wang S, Castro BA, Katz JL, Arrieta V, Najem H, Vazquez-Cervantes GI, Wan H, Olson IE, Hou D, Dapash M, Billingham LK, Chia TY, Wei C, Rashidi A, Platanias LC, McCortney K, Horbinski CM, Stupp R, Zhang P, Ahmed AU, Sonabend AM, Heimberger AB, Lesniak MS, Riviere-Cazaux C, Burns T, Miska J, Fischietti M, Lee-Chang C, B cell-based therapy produces antibodies that inhibit glioblastoma growth. J Clin Invest, 134(20):(2024) [pubmed]
10.1172/jci177384;
Keyword List
submitter keyword: Glioblastoma multiforme (GBM)
B-cell-based vaccine (BVax)
Tumor-reactive antibodies
Immunoproteomics
Contact List
Ctalina Lee-Chang
contact affiliationNorthwestern University
contact emailcatalina.leechang@northwestern.edu
lab head
Si Wang
contact affiliationNorthwestern University
contact emailsi.wang@northwestern.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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